The induction of neoangiogenesis is a critical step already present at the early stages of
tumor development and dissemination. The progressive identification of molecules playing a …

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Initiation, development and malignant progression of tumors depend on multiple genetic
alterations as well as posttranscriptional and posttranslational modifications within the tumor …

The growth and dissemination of tumors rely on an altered vascular network, which supports
their survival and expansion and provides accessibility to the vasculature and a route of …

Formation of new blood vessels (angiogenesis) has been demonstrated to be a basic
prerequisite for sustainable growth and proliferation of tumor. Several growth factors …

Angiogenesis is required for invasive tumor growth and metastasis and constitutes an
important point in the control of cancer progression. Its inhibition may be a valuable new …

Current attempts to disrupt the complex process of tumor blood vessel formation are
predominantly focused on targeting the vascular endothelial growth factor (VEGF)–VEGFR …

Angiogenesis–the formation of new blood vessels within a tumor (or many other tissue
types)–has become a hotbed of pharmacological research as well as industrial drug …

Tumors have been recently recognized as aberrant organs composed of a complex mixture
of highly interactive cells that in addition to the cancer cell include stroma (fibroblasts …

Angiogenesis—the formation of new blood vessels—is essential for tumour progression and
metastasis. Consequently, the modulation of tumour angiogenesis using novel agents has …