Inhibitors of angiogenesis in a clinical perspective

EE Voest - Anti-Cancer Drugs, 1996 - journals.lww.com
Inhibition of angiogenesis or preventing the outgrowth of new blood vessels towards a tumor
is one of the most promising areas of anticancer drug development. Several angiogenesis …

Redefining the target: chemotherapeutics as antiangiogenics

KD Miller, CJ Sweeney, GW Sledge Jr - Journal of clinical oncology, 2001 - ascopubs.org
Angiogenesis, or new blood vessel formation, is now known to play an important role in both
growth and metastasis of many cancers. The central importance of angiogenesis and the …

Tumor angiogenesis and vascular normalization: alternative therapeutic targets

C Viallard, B Larrivée - Angiogenesis, 2017 - Springer
Tumor blood vessels are a key target for cancer therapeutic management. Tumor cells
secrete high levels of pro-angiogenic factors which contribute to the creation of an abnormal …

Promises and pitfalls of anti-angiogenic therapy in clinical trials

MF McCarty, W Liu, F Fan, A Parikh, N Reimuth… - Trends in molecular …, 2003 - cell.com
A significant body of research has implicated the process of angiogenesis in the growth and
spread of tumors. Elucidation of the mechanisms of tumor angiogenesis has led to the …

Antiangiogenic and antivascular therapy for cancer

G Taraboletti, B Margosio - Current opinion in pharmacology, 2001 - Elsevier
The great interest in the potential antineoplastic effect of targeting tumor-associated blood
vessels has generated an expanding armamentarium of therapeutic tools that include …

Angiogenesis and cancer: a cross-talk between basic science and clinical trials (the “do ut des” paradigm)

G de Castro Junior, F Puglisi, E de Azambuja… - Critical reviews in …, 2006 - Elsevier
Angiogenesis plays a crucial role in facilitating tumor growth and the metastatic process, and
it is the result of a dynamic balance between pro-angiogenic factors, like vascular …

Tumor angiogenesis: molecular pathology, therapeutic targeting, and imaging

WW Li - Academic radiology, 2000 - Elsevier
Angiogenesis, the growth of new blood vessels, is a fundamental physiological process
required for development, reproduction, and wound repair and as a tissue response to …

[HTML][HTML] Current concerns and challenges regarding tailored anti-angiogenic therapy in cancer

DH Roukos, A Tzakos, G Zografos - Expert Review of Anticancer …, 2009 - Taylor & Francis
Anti-angiogenic therapy in cancer has become very popular. Agents inhibiting new vessel
formation (angiogenesis) and blood supply can have anticancer effects. This idea …

New strategies in anti‐vascular cancer therapy

Bloemendal, Logtenberg, Voest - European journal of clinical …, 1999 - Wiley Online Library
Angiogenesis is a critical step in the progression of tumours from dormancy to a clinical
relevant cancer. Inhibition of this process is one of the most promising new anti‐cancer …

[HTML][HTML] Anti-angiogenesis or pro-angiogenesis for cancer treatment: focus on drug distribution

D Huang, H Lan, F Liu, S Wang, X Chen… - … journal of clinical and …, 2015 - ncbi.nlm.nih.gov
Enhancing chemotherapy delivery to tumors, improving tumor growth control, reducing
metastasis, and increasing survival are all critical objectives of improved cancer therapy …