PURPOSE: DNA methylation contributes to carcinogenesis by mediating transcriptional
regulation and chromatin remodelling, which may influence the effect of DNA-damaging …

AIM: To explore the alteration of DNA methyltransferase expression in gastric cancer and to
assess its prognostic value. METHODS: From April 2000 to December 2010, 227 men and …

Abstract DNA methyltransferase (DNMT) 1, DNMT3A and DNMT3B, which affect promoter
CpG methylation status, play a significant role in cancer development. Little is known …

Gastric cancer is a major health problem worldwide occupying most frequent causes of
cancer-related mortality. In addition to genetic modifications, epigenetic alterations catalyzed …

Background Altered gene methylation, regulated by DNA methyltransferases (DNMT) 1, 3a
and 3b, contributes to tumorigenesis. However, the role of DNMT in pancreatic ductal …

BACKGROUND: The identification of potential tumor markers can improve therapeutic
planning and patient management. The objective of this study was to highlight the role of …

DNA methyltransferase I (DNMT1) is the major methyltransferase responsible for
methylating DNA and is overexpressed in many cancers. DNMT1 is also a therapeutic target …

We evaluated the significance of aberrant DNA methyltransferase 1 (DNMT1) protein
expression during gastric carcinogenesis. The protein expression of DNMT1, Muc2, human …

DNA methylation is an epigenetic phenomenon known to play an important role in the
development and progression of human cancer. Enzyme responsible for this process is DNA …

Gastric cancer is the second most common cause of cancer deaths worldwide. The
identification of molecular genetic parameters that are associated with response to …