To develop a strategy for efficacious intervention in order to prevent or treat various cancers,
one must understand the basic mechanism (s) by which various anticancer dietary factors …

The development of the most efficacious strategy for the prevention and treatment of cancers
is based on understanding the underlying mechanisms of carcinogenesis. This includes the …

Chemopreventive or chemotherapeutic agents have been those that either kill cancer cells
to a differential degree over the non‐cancer cells or those chemicals that either block the …

Since carcinogenesis is a multi-stage, multi-mechanism process, involving mutagenic, cell
death and epigenetic mechanisms, during the “initiation/promotion/and progression” …

In spite of the early speculation by Loewenstein that one of the critical distinguishing
phenotypes of cancers from normal cells was the dysfunction of gap junctional intercellular …

If occupational tumors are excluded, cancer causes are largely unknown. Therefore, it
appeared useful to work out a theory explaining the complexity of this disease. More than …

Most, if not all, cancer cells have some dysfunction in gap-junction-mediated intercellular
communication, either because of defects in cell adhesion or inability to have functional gap …

Understanding the process of carcinogenesis will involve both the accumulation of many
scientific facts derived from molecular, biochemical, cellular, physiological, whole animal …

Cells within a tissue continuously interact to coordinate normal tissue functions and maintain
homeostasis. Gap junctional communication (GJC), mediated by the connexin protein family …

Dietary phytochemicals offer protection from oxidative damages and lower the risks of
chronic diseases, by complementary and overlapping action mechanisms. These include …