Dihydromyricetin alleviates sepsis-induced acute lung injury through inhibiting NLRP3 inflammasome-dependent pyroptosis in mice model

Y Wang, Q Liu, Q Zheng, T Liu, X Xu, X Liu, W Gao… - Inflammation, 2019 - Springer
Increasing evidence demonstrates that pyroptosis, pro-inflammatory programmed cell death,
is linked to acute lung injury (ALI). Dihydromyricetin (DHM) has been reported to exert anti …

Emodin Attenuates LPS-Induced Acute Lung Injury by Inhibiting NLRP3 Inflammasome-Dependent Pyroptosis Signaling Pathway In vitro and In vivo

Y Liu, L Shang, J Zhou, G Pan, F Zhou, S Yang - Inflammation, 2022 - Springer
Emodin, the effective component of the traditional Chinese medicine Dahuang, has anti-
inflammatory effects. However, the protective effects and potential mechanisms of emodin …

[HTML][HTML] Quercetin protects against LPS-induced lung injury in mice via SIRT1-mediated suppression of PKM2 nuclear accumulation

L Chen, C Song, Y Zhang, Y Li, Y Zhao, F Lin… - European Journal of …, 2022 - Elsevier
The role of NOD-like receptor protein 3 (NLRP3)-mediated macrophages pyroptosis in acute
lung injury (ALI) is well-established. Quercetin (Que) is a natural bioflavonoid compound …

Tangeretin attenuates acute lung injury in septic mice by inhibiting ROS-mediated NLRP3 inflammasome activation via regulating PLK1/AMPK/DRP1 signaling axis

Y Liu, Y Zhang, G You, D Zheng, Z He, W Guo… - Inflammation …, 2024 - Springer
Objective NLRP3 inflammasome-mediated pyroptosis of macrophage acts essential roles in
the progression of sepsis-induced acute lung injury (ALI). Tangeretin (TAN), enriched in …

Buformin alleviates sepsis-induced acute lung injury via inhibiting NLRP3-mediated pyroptosis through an AMPK-dependent pathway

B Liu, Z Wang, R He, R Xiong, G Li, L Zhang… - Clinical …, 2022 - portlandpress.com
Background: NOD-like receptor family pyrin domain containing 3 (NLRP3)-mediated
macrophage pyroptosis plays an important role in sepsis-induced acute lung injury (ALI) …

Dihydromyricetin inhibits NLRP3 inflammasome‐dependent pyroptosis by activating the Nrf2 signaling pathway in vascular endothelial cells

Q Hu, T Zhang, L Yi, X Zhou, M Mi - Biofactors, 2018 - Wiley Online Library
Increasing evidence demonstrates that pyroptosis, pro‐inflammatory programmed cell
death, is linked to atherosclerosis; however, the underlying mechanisms remain to be …

[HTML][HTML] Regulation of the NLRP3 inflammasome and macrophage pyroptosis by the p38 MAPK signaling pathway in a mouse model of acute lung injury

D Li, W Ren, Z Jiang, L Zhu - Molecular medicine …, 2018 - spandidos-publications.com
Acute lung injury and acute respiratory distress syndrome (ALI/ARDS) is characterized by
uncontrolled progressive lung inflammation. Macrophages serve a key role in the …

Honokiol alleviates LPS-induced acute lung injury by inhibiting NLRP3 inflammasome-mediated pyroptosis via Nrf2 activation in vitro and in vivo

Y Liu, J Zhou, Y Luo, J Li, L Shang, F Zhou, S Yang - Chinese medicine, 2021 - Springer
Background Honokiol (HKL) has been reported to ameliorate lipopolysaccharide (LPS)-
induced acute lung injury (ALI). However, its potential mechanism of its protective effects …

Puerarin ameliorates acute lung injury by modulating NLRP3 inflammasome-induced pyroptosis

D Cai, Y Zhao, F Yu - Cell death discovery, 2022 - nature.com
We commenced to analyze putative anti-pyroptosis effects of puerarin (PU) as mediated by
the PP2A-HDAC1-NLRP3 pathway in acute lung injury (ALI). ALI animal and cell models …

Metformin alleviates LPS-induced acute lung injury by regulating the SIRT1/NF-κB/NLRP3 pathway and inhibiting endothelial cell pyroptosis

Y Zhang, H Zhang, S Li, K Huang, L Jiang… - Frontiers in …, 2022 - frontiersin.org
Acute respiratory distress syndrome (ARDS), a devastating complication of numerous
conditions, is often associated with high mortality. It is well known that endothelial cell (EC) …