Reperfusion of the ischemic myocardium results in irreversible tissue injury and cell
necrosis, leading to decreased cardiac performance. While early reperfusion of the heart is …

In patients with an acute ST-segment elevation myocardial infarction, timely myocardial
reperfusion using primary percutaneous coronary intervention is the most effective therapy …

Critically timed reperfusion is a prerequisite for survival of ischaemic myocardium. However,
reperfusion may have an injurious component, which in experimental models appears to be …

Background: Early reperfusion of the blocked vessel is critical to restore the blood flow to the
ischemic myocardium to salvage myocardial tissue and improve clinical outcome. This …

It has been documented that Ca 2+ overload and increased production of reactive oxygen
species play a significant role in reperfusion injury (RI) of cardiomyocytes …

Despite tremendous advances in cardiovascular research and clinical therapy, ischemic
heart disease remains the leading cause of serious morbidity and mortality in western …

Background: Oxidative stress due to reactive oxygen species (ROS) is thought to play a
considerable role in ischemia/reperfusion (I/R) injury that impairs cardiac function. The …

Acute myocardial infarction (AMI) is the leading cause of mortality worldwide. Major
advances in the treatment of acute coronary syndromes and myocardial infarction, using …

Cardiac ischemia reperfusion injury (IRI) occurs when the myocardium is revascularized
after an episode of limited or absent blood supply. Many changes, including free radical …

The evidence supporting the toxicity of oxygen-derived free radicals in the setting of
myocardial ischemia has grown considerably during the past few years. 1, 2 There is also …