Does reperfusion injury exist in humans?

RA Kloner - Journal of the American College of Cardiology, 1993 - Elsevier
Timely coronary reperfusion as treatment for acute myocardial infarction reduces myocardial
infarct size, improves left ventricular function and survival. There is still concern that at the …

Progression in attenuating myocardial reperfusion injury: an overview

FJP Bernink, L Timmers, AM Beek, M Diamant… - International journal of …, 2014 - Elsevier
Reperfusion by means of percutaneous coronary intervention or thrombolytic therapy is the
most effective treatment for acute myocardial infarction, markedly reducing mortality and …

Pathobiology of myocardial ischemia and reperfusion injury: models, modes, molecular mechanisms, modulation, and clinical applications

LM Buja - Cardiology in Review, 2023 - journals.lww.com
This review presents an integrated approach to the analysis of myocardial ischemia and
reperfusion injury and the modulating influence of myocardial conditioning during the …

Myocardial reperfusion injury

G Ambrosio, I Tritto - European Heart Journal Supplements, 2002 - academic.oup.com
Post-ischaemic reperfusion carries an injurious component that may partly counteract the
beneficial effects of reflow; this component has been termed 'reperfusion injury'. Principal …

Pathophysiology of ischaemia-reperfusion injury

M Sirotković-Skerlev, S Plestina, I Bilić, Z Kovac - Lijecnicki vjesnik, 2006 - europepmc.org
Reperfusion of ischaemic tissue provides oxygen and substrates that are necessary for
tissue recovery and concurrently removes toxic metabolites. However, reperfusion may …

Pharmacological possibilities for protection against myocardial reperfusion injury

QD Wang, J Pernow, PO Sjöquist… - Cardiovascular …, 2002 - academic.oup.com
Reperfusion through thrombolysis or percutananeous coronary angioplasty is standard
treatment in impending acute myocardial infarction. Although restoration of blood flow to the …

Myocardial ischemia/reperfusion injury: Mechanisms of injury and implications for management

J He, D Liu, L Zhao, D Zhou… - Experimental and …, 2022 - spandidos-publications.com
Myocardial infarction is one of the primary causes of mortality in patients with coronary heart
disease worldwide. Early treatment of acute myocardial infarction restores blood supply of …

Effects of endogenous cardioprotective mechanisms on ischemia-reperfusion injury

M Kunecki, W Płazak, P Podolec, KS Gołba - Advances in Hygiene and …, 2017 - phmd.pl
Ischemic heart disease have been remarked as a leading cause of morbidity and mortality in
adults. Early restoration of cardiac perfusion is necessary to restore perfusion of ischemic …

Reperfusion injury in humans: a review of clinical trials on reperfusion injury inhibitory strategies

MT Dirksen, GJ Laarman, ML Simoons… - Cardiovascular …, 2007 - academic.oup.com
The principal therapy in patients with myocardial infarction to limit infarct size is myocardial
reperfusion by mechanical or pharmacological intervention. Reperfusion has been …

Does reperfusion induce myocardial necrosis?

T Miura - Circulation, 1990 - Am Heart Assoc
Reperfusion Injury While coronary thrombolytic therapy in clinical practice is well
established for acute myocardial infarction, the injury associated with reperfusion (" …