Gene therapy approaches based on adeno-associated viral vector (AAV) systems offer
many unique advantages for nervous system applications. These vectors are opening up …

Adeno‐associated virus (AAV) vectors are able to transduce CNS cells in vitro and in vivo for
extended periods of time without immune complications. The ability to efficiently deliver …

Adeno-associated virus (AAV) shows significant potential as a gene delivery system.
Although it is ubiquitous in its distribution, with approximately 85% of the adult population in …

The use of viral vectors as agents for gene delivery provides a direct approach to manipulate
gene expression in the mammalian central nervous system (CNS). The present article …

Vectors based on adeno-associated virus (AAV) have recently been used in phase I clinical
trials for the treatment of neurological disorders, such as Parkinson's and Canavan's …

Transgenic strategies are useful for funcional studies and they may also lead to novel
therapies. Controlling transgene expression in defined cell populations over time is …

Several neurodevelopmental and neurodegenerative disorders affecting the central nervous
system are potentially treatable via viral vector-mediated gene transfer. Adeno-associated …

Gene therapy is a novel method under investigation for the treatment of neurological
disorders. Considerable interest has focused on the possibility of using viral vectors to …

Gene therapy has strong potential for treating a variety of genetic disorders, as
demonstrated in recent clinical trials. There is unfortunately no scarcity of disease targets …

The realization of gene therapy for the central nervous system has advanced to the realmsof
clinical practice. The brain and spinal cord, once inaccessible to certain therapies …