Recent insights into novel roles of klotho in vascular biology make this primarily kidney-
derived protein a possible candidate to form a link between chronic kidney disease and …

Aims Cardiovascular disease (CVD) is the leading cause of death in patients with chronic
kidney disease (CKD), a disease state that is strongly associated with loss of renal and …

Abstract Background: Cardiovascular diseases (CVDs) are the leading cause of morbidity
and mortality in advanced CKD. The major pathological changes of CKD-associated CVD …

A decreased expression of the fibroblast growth factor (FGF)-23 coreceptor Klotho was
postulated as an early alteration in chronic kidney disease mineral and bone disorder …

Klotho is a single‐pass transmembrane protein predominantly expressed in the kidney. The
extracellular domain of Klotho is subject to ectodomain shedding and is released into the …

Klotho is a novel renoprotective anti-aging protein available in membrane-bound or soluble
form. Klotho is expressed in brain, pancreas, and other solid organs but shows highest …

Background Klotho gene was identified as an aging suppressor. In animals, klotho
overexpression extends life span, and defective klotho results in rapid aging and early …

α-Klotho (Klotho) exists in two different forms, a membrane-bound and soluble form, which
are highly expressed in the kidney. Both forms play an important role in various …

Abstract Background Soluble Klotho has multiple systemic salutary effects. In animals, both
acute and chronic kidney disease models display systemic Klotho deficiency. As such, there …

Abstract αKlotho (called Klotho here) is a membrane protein that serves as the coreceptor for
the circulating hormone fibroblast growth factor 23 (FGF23). Klotho is also cleaved and …