Background Klotho was originally identified in a mutant mouse strain unable to express the
gene that consequently showed shortened life spans. In humans, low serum Klotho levels …

Klotho gene mutation leads to a syndrome strangely resembling chronic kidney disease
patients undergoing dialysis with multiple accelerated age-related disorders, including …

The klotho gene (KL) was identified first as a putative aging-suppressor gene that extended
life span when overexpressed and accelerated aging-like phenotypes when disrupted in …

Klotho, named after a Greek goddess who spins the thread of life, was identified in 1997 as
a gene mutated in a mouse strain that developed a premature ageing syndrome [1]. A defect …

Background αKlotho is the prototypic member of the Klotho family and is most highly
expressed in the kidney. αKlotho has pleiotropic biologic effects, and in the kidney, its …

To investigate whether the soluble Klotho (s-Klotho) level in patients with chronic kidney
disease (CKD) is related to kidney function and whether a low s-Klotho level can predict …

Klotho is a single-pass transmembrane protein that is highly expressed in the kidney and is
known to act as a coreceptor for fibroblast growth factor 23. The extracellular domain can be …

Klotho, a transmembrane protein, protease, and hormone mainly expressed in renal tissue
counteracts aging. Overexpression of Klotho substantially prolongs the life span. Klotho …

CKD appears to be a condition of soluble klotho deficiency. Despite known associations
between low soluble klotho levels and conditions that promote kidney damage, such as …

Klotho is a membrane-bound protein acting as an obligatory coreceptor for fibroblast growth
factor 23 (FGF23) in the kidney and parathyroid glands. The extracellular portion of its …