Background: Membrane αKlotho (hereinafter called Klotho) is highly expressed in the kidney
and functions as a coreceptor of FGF receptors (FGFRs) to activate specific fibroblast growth …

The Klotho gene has been identified as an aging suppressor gene that encodes a
transmembrane protein, which is expressed primarily in renal tubules. There are 2 forms of …

Ageing is a multifactorial process often characterized by a progressive decline in
physiological function (s). Ageing can and is often associated with an increased incidence of …

Abstract Objective Soluble serum Klotho is a new biomarker linked to chronic kidney
disease, cardiovascular disease and diabetes. This study describes the evaluation and …

Klotho has been recognized as a gene involved in the aging process in mammals for over
30 years, where it regulates phosphate homeostasis and the activity of members of the …

Klotho was discovered as an antiaging gene, and α-Klotho (Klotho) is expressed in multiple
tissues with a broad set of biologic functions. Membrane-bound Klotho binds fibroblast …

Background Klotho is a transmembrane protein acting as a co-receptor for FGF-23 and thus
exerts clinical actions on mineral metabolism. The association of secreted Klotho with …

Klotho-deficient mice have accelerated aging phenotypes, whereas overexpression of
Klotho in mice extends lifespan. Klotho is an anti-aging single-pass membrane protein …

Abstract αKlotho (Klotho), a type I transmembrane protein and a coreceptor for Fibroblast
Growth Factor-23, was initially thought to be expressed only in a limited number of tissues …

Background Dialysis patients suffer from a high burden of cardiovascular disease (CVD).
Partly this is due to progressive deterioration of calcium-phosphate homeostasis. Previous …