Background Klotho, a protein linked to aging, has emerged as a pivotal player in mineral
bone metabolism and might explain the relationship between chronic kidney disease (CKD) …

Cardiac dysfunction in CKD is characterized by aberrant cardiac remodeling with
hypertrophy and fibrosis. CKD is a state of severe systemic Klotho deficiency, and …

Klotho has antiaging properties, and serum levels decrease with physiological aging and
aging-related diseases, such as hypertension, cardiovascular, and chronic kidney disease …

Sixteen years ago, defective expression of the murine klotho gene was found to result in a
syndrome resembling human aging. 1 Tubular kidney cells were the main sites of Klotho …

Klotho is a membrane-bound protein predominantly expressed in the kidney, where it acts
as a permissive co-receptor for Fibroblast Growth Factor 23. In its shed form, Klotho exerts …

Background: Klotho is highly expressed in the kidney, is present in the circulation and urine,
and has protective effects against various renal injuries. We examined whether reduced …

Objective. Over decades, numerous inconsistent studies are reported on the relationship
between soluble α‐Klotho and renal function in patients with chronic kidney disease (CKD) …

Klotho was identified as the responsible gene in a mutant mouse line whose disruption
results in a variety of premature aging-related phenotypes. Nonetheless, the related …

Klotho is a putative aging suppressor gene encoding a single-pass transmembrane co-
receptor that makes the fibroblast growth factor (FGF) receptor specific for FGF-23. In …

Klotho was initially introduced as an antiaging molecule. Klotho deficiency significantly
reduces lifespan, and its overexpression extends it and protects against various pathological …