BACKGROUND: α-Klotho is reported to have protective effects against kidney injury, and its
renal expression is decreased in many experimental models of kidney disease. However …

Renal expression of the klotho gene is markedly suppressed in chronic kidney disease
(CKD). Since renal fibrosis is the final common pathology of CKD, we tested whether …

Background/Aims: Defects in klotho gene expression in the mouse result in a syndrome that
resembles human aging. We recently identified expression of klotho in a mouse inner …

A unique short lifespan mouse strain was developed in which a single gene mutation
caused multiple aging-related disorders. The gene responsible has been identified as the …

The anti-aging gene klotho plays an important role in Ca2+ and phosphate homeostasis.
Membrane-bound klotho is an essential coreceptor for fibroblast growth factor-23 and can …

Osteocytes within the mineralized bone matrix control bone remodeling by regulating
osteoblast and osteoclast activity. Osteocytes express the aging suppressor Klotho, but the …

The Klotho gene was identified as an 'aging suppressor'in mice. Overexpression of the
Klotho gene extends lifespan and defective Klotho results in rapid aging and early death …

Background and Purpose Klotho is a membrane‐bound or soluble protein, originally
identified as an age‐suppressing factor and regulator of mineral metabolism. Klotho …

OBJECTIVES: Both kidney expression and soluble serum Klotho are influenced by chronic
kidney disease (CKD) and diabetes. Serum Klotho is a yet poorly explored biomarker. We …

Diabetic nephropathy (DN) is the leading cause of end-stage renal disease worldwide and
is a significant burden on healthcare systems. α-klotho (klotho) is a protein known for its anti …