Developments of many renal diseases are substantially influenced by epigenetic
modifications of numerous genes, mainly mediated by DNA methylations, histone …

Klotho is a protein of significant importance for mineral homeostasis. It helps to increase
parathyroid hormone (PTH) secretion and in the trafficking of Na+/K+-ATPase to the cell …

Renal expression of klotho is reduced in hypertension. Experiments were performed to
examine whether exogenous klotho protein supplementation ameliorates pressure …

Results The median klotho concentration was 630 pg/ml (478–816, 25th to 75th percentile).
Within the cohort, 2093 (76%) of 2774 participants had prevalent hypertension and 476 …

The klotho gene encodes a type I single-pass transmembrane protein that contains a large
extracellular domain, a membrane spanning segment, and a short intracellular domain …

BACKGROUND: Klotho, a single-pass transmembrane protein primarily expressed in the
kidneys, parathyroid glands, and choroid plexus of the brain, has a short cytoplasmic tail and …

Renal Klotho controls mineral metabolism by directly modulating tubular reabsorption of
phosphate and calcium and by acting as a co-receptor for the phosphaturic and vitamin D …

Introduction It has been reported that klotho deficiency is associated with oxidative stress
and inflammation in experimental kidney disease models. Patients with end-stage renal …

This study was designed to investigate the controversy on the potential role of sKlotho as an
early biomarker in Chronic Kidney Disease–Mineral Bone Disorder (CKD-MBD), to assess …