A comparison of the sensitivity of blood and bone marrow for the detection of minimal residual disease in chronic myeloid leukaemia

F Lin, JM Goldman, NCP Cross - British journal of haematology, 1994 - Wiley Online Library
We have sought to determine whether peripheral blood or bone marrow is more sensitive for
assessment of minimal residual disease in chronic myeloid leukaemia (CML) …

Minimal residual disease in chronic myeloid leukaemia.

NC Cross - Hematology and cell therapy, 1998 - europepmc.org
The principle aim of residual disease analysis in patients with chronic myeloid leukaemia
(CML) is to gauge patient response to treatment and, in patients after allogeneic BMT, to …

Minimal residual disease after bone marrow transplant for chronic myeloid leukaemia detected by the polymerase chain reaction

NCP Cross, L Feng, J Bungey… - Leukemia & …, 1993 - Taylor & Francis
We describe the methodology and application of the polymerase chain reaction to detect
BCR-ABL mRNA as a marker for CML cells. The technique is highly sensitive enabling the …

Detection of minimal residual disease by polymerase chain reaction of bcr/abl transcripts in chronic myelogenous leukaemia following allogeneic bone marrow …

M Lee, I Khouri, R Champlin… - British journal of …, 1992 - Wiley Online Library
The prognostic significance of detecting minimal residual disease by polymerase chain
reaction (PCR) amplification of bcr/abl mRNA transcripts was investigated in 27 bone …

Frequent detection of minimal residual disease by use of the polymerase chain reaction in long-term survivors after bone marrow transplantation for chronic myeloid …

JM Pignon, T Henni, S Amselem, M Vidaud… - Leukemia, 1990 - europepmc.org
The polymerase chain reaction (PCR) allows the detection of minimal amounts of nucleic
sequences and has been successfully used to test for the chronic myeloid leukemia-specific …

Quantitation of minimal residual disease in Philadelphia chromosome positive chronic myeloid leukaemia patients using real‐time quantitative RT‐PCR

Menskin, V De Locht, Schattenberg… - British journal of …, 1998 - Wiley Online Library
We used a recently developed system for real‐time quantitative polymerase chain reaction
(PCR) to determine residual disease in patients with chronic myeloid leukaemia. The …

Monitoring chronic myeloid leukaemia therapy by real‐time quantitative PCR in blood is a reliable alternative to bone marrow cytogenetics

Branford, Hughes, Rudzki - British journal of haematology, 1999 - Wiley Online Library
We have developed a rapid real‐time quantitative PCR method for measuring BCR‐ABL
mRNA levels in peripheral blood in chronic myeloid leukaemia (CML). The technique was …

Competitive polymerase chain reaction to estimate the number of BCR-ABL transcripts in chronic myeloid leukemia patients after bone marrow transplantation

NC Cross, L Feng, A Chase, J Bungey, TP Hughes… - 1993 - ashpublications.org
We have developed a competitive polymerase chain reaction (PCR) titration assay that
estimates the number of BCR-ABL transcripts in chronic myeloid leukemia patients to …

Monitoring of residual disease in chronic myelogenous leukemia by quantitative polymerase chain reaction and clinical decision making

T Lion - Blood, The Journal of the American Society of …, 1999 - ashpublications.org
In the May 1, 1999 issue of Blood, Faderl et al1 discuss the possible clinical role of
polymerase chain reaction (PCR) analysis in the surveillance of residual disease in patients …

Detection of residual BCR/ABL transcripts in chronic myeloid leukaemia patients in complete remission using the polymerase chain reaction and nested primers

P Martiat, D Maisin, M Philippe… - British journal of …, 1990 - Wiley Online Library
We sought evidence of BCR/ABL transcripts in the peripheral blood of nine CML patients in
complete clinical and cytogenetic remission after treatment by bone marrow transplantation …