For the great majority of patients with chronic myeloid leukaemia (CML), the Philadelphia
(Ph) chromosome is a specific marker of the malignant clone. The standard method to …

Optimal sample quality is a prerequisite to generate valid data in the detection of minimal
residual disease (MRD) in leukemias. Thus, the risk of obtaining 'false'-negative results is …

We prospectively studied 98 chronic myeloid leukemia (CML) patients after bone marrow
transplantation by competitive polymerase chain reaction to detect and quantify leukemia …

We have used a new single‐step real‐time reverse transcription polymerase chain reaction
(RT‐PCR) method to quantify BCR‐ABL transcripts, thereby estimating the relapse stage in …

Approximately half of patients with chronic myeloid leukemia (CML) in sustained deep
molecular response who discontinue tyrosine kinase inhibitors (TKIs) remain in treatment …

Fifteen consecutive patients with Philadelphia chromosome (Ph)‐positive chronic myeloid
leukaemia (CML) who relapsed from T‐cell‐depleted bone marrow transplantation (BMT) …

Two hundred and nineteen cases of Ph+ ve CML and 15 Ph‐ve, BCR+ ve CML cases have
been analysed to determine the breakpoint site and its relationship to clinical features …

In order to understand better the mechanism of translocation between the BCR and ABL
genes in CML, we have exploited a 'bubble PCR'technique to clone genomic breakpoints …

The bcr-abl chimeric messenger RNA is frequently detected in chronic myeloid leukemia
(CML) patients after bone marrow transplantation. It was previously reported that the relapse …

Hypermetaphase FISH (HMF), a molecular cytogenetic procedure combining the long term
mitotic arrest of bone marrow cultures with detection of a specific chromosomal …