Multiple studies have recognized the involvement of the complement cascade during
Alzheimer's disease pathogenesis. However, the specific role of C5a-C5aR1 signaling in the …

Background Pharmacologic inhibition of C5aR1, a receptor for the complement activation
proinflammatory fragment, C5a, suppressed pathology and cognitive deficits in Alzheimer's …

Background The complement system is part of the innate immune system that clears
pathogens and cellular debris. In the healthy brain, complement influences …

Alzheimer's disease (AD) is the leading cause of dementia in older adults, and the need for
effective, sustainable therapeutic targets is imperative. The complement pathway has been …

Alzheimer's disease (AD) is an age-related dementia, characterized by amyloid plaques,
neurofibrillary tangles, neuroinflammation, and neuronal loss in the brain. Components of …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the most
common cause of dementia among the elderly population. Despite its widespread …

Background Alzheimer's disease (AD) is a neurodegenerative dementia characterized by
the decline of cognition and the presence of neuropathological changes including neuronal …

Increasing evidence supports a role of neuroinflammation in the pathogenesis of
Alzheimer's disease (AD). Previously, we identified a neuron–glia signaling pathway …

There is evidence that the complement system, a major component of inflammatory
responses, may play an important role in neurodegenerative conditions such as Alzheimer's …

C5aR1, the proinflammatory receptor for C5a, is expressed in the central nervous system on
microglia, endothelial cells, and neurons. Previous work demonstrated that the C5aR1 …