Inflammation in the central nervous system (CNS) is a common feature of age-related
neurodegenerative diseases. Proinflammatory cytokines, such as IL-1β and TNFα, are …

Background An accumulating body of evidence is consistent with the hypothesis that
excessive or prolonged increases in proinflammatory cytokine production by activated glia is …

Background Overproduction of proinflammatory cytokines from activated microglia has been
implicated as an important contributor to pathophysiology progression in both acute and …

Mammalian p38 mitogen-activated protein kinases (MAPKs) are activated by various cellular
stresses, as well as in response to inflammatory cytokines. In the central nervous systems …

Background The p38α MAPK isoform is a well-established therapeutic target in peripheral
inflammatory diseases, but the importance of this kinase in pathological microglial activation …

The p38 MAPK protein kinases affect a variety of intracellular responses, with well-
recognized roles in inflammation, cell-cycle regulation, cell death, development …

A significant amount of evidence suggests that the p38‐mitogen‐activated protein kinase
(MAPK) signalling cascade plays a crucial role in synaptic plasticity and in …

A majority, if not all, acute and progressive neurodegenerative diseases are accompanied
by local microglia‐mediated inflammation, astrogliosis, infiltration of immune cells, and …

P38 mitogen-activated protein kinase (MAPK) is a crucial target for chronic inflammatory
diseases. Alzheimer's disease (AD) is characterized by the presence of amyloid plaques …

Mammalian p38 mitogen-activated protein kinases (MAPKs) are activated by a wide range
of cellular stresses as well as in response to inflammatory cytokines. There are four …