Tuberculosis (TB) is a zoonotic infectious disease caused by Mycobacterium tuberculosis
(Mtb). Mtb is a typical intracellular parasite, and macrophages are its main host cells. NLRP3 …

The nucleotide-binding domain and leucine-rich repeat protein 3 (NLRP3) inflammasome
has developed as an important bridge between innate immune and infection recently, and …

Proinflammatory cytokines of the IL‐1 family play an important role for the anti‐mycobacterial
host defense mechanisms. In the present study we have deciphered the pathways leading …

Citrobacter freundii is a significant cause of human infections, responsible for food
poisoning, diarrhea, and urinary tract infections. We previously identified a highly cytotoxic …

Citrobacter rodentium is an enteric bacterial pathogen of the mouse intestinal tract that
triggers inflammatory responses resembling those of humans infected with …

Mycobacterium tuberculosis (MTB) infection is characterized by granulomatous lung lesions
and systemic inflammatory responses during active disease. Inflammasome activation is …

The innate immune system recognizes pathogens/antigens via several families of pattern
recognition receptors (PRRs). Often, several PRRs will be triggered, resulting in an innate …

Cryptococcus is one of the most pathogenic invasive fungi, and its interaction with the host's
natural immunity, especially the role of the inflammasome family, has not been fully …

Inflammasomes are intracellular signaling complexes that are assembled in response to a
variety of pathogenic or physiologic stimuli to initiate inflammatory responses. Ubiquitously …

Gut commensal bacteria contribute to the pathogenesis of inflammatory bowel disease, in
part by activating the inflammasome and inducing secretion of interleukin-1ß (IL-1ß) …