Microbial sensing plays essential roles in the innate immune response to pathogens. In
particular, NLRP3 forms a multiprotein inflammasome complex responsible for the …

Acinetobacter baumannii is a multi‐drug resistant, Gram‐negative bacteria and infection
with this organism is one of the major causes of mortality in intensive care units …

Candida albicans is a well-tolerated resident of human mucosal tissues. This implies that
host defense mechanisms cooperate to limit inflammation while controlling fungal burden …

The inflammasomes are intracellular multimeric protein complexes consisting of an innate
immune sensor, the adapter protein ASC and the inflammatory caspases-1 and/or-11 and …

The innate immune response to Trypanosoma cruzi infection comprises several pattern
recognition receptors (PRRs), including TLR-2,-4,-7, and-9, as well as the cytosolic receptor …

We demonstrate that Mycobacterium tuberculosis recombinant leucine-responsive
regulatory protein (rLrp) inhibits lipopolysaccharide (LPS)-induced tumor necrosis factor …

Objective: Despite the antiretroviral treatment, people with HIV (PWH) still experience
systemic chronic inflammation and immune-senescence, which represent risk factors for …

The NOD-like receptor family, pyrin domain-containing 3 (NLRP3) inflammasome plays
pivotal roles in inflammation and autoimmunity. The NLRP3 inflammasome is activated in …

Bacteria-released components can modulate host innate immune response in the absence
of direct host cell–bacteria interaction. In particular, bacteria-derived outer membrane …

TLRs and NLRs participate in the immune system recognition of Helicobacter pylori.
However, little is known about the mechanisms leading to inflammasome activation by H …