Recognition of microbial infection by certain intracellular pattern recognition receptors leads
to the formation of a multiprotein complex termed the inflammasome. Inflammasome …

Pathogen-triggered activation of the inflammasome complex leading to caspase-1 activation
and IL-1β production involves similar sensor proteins between mouse and human. However …

Candida albicans and C. parapsilosis are human pathogens causing severe infections. The
NLRP3 inflammasome plays a crucial role in host defence against C. albicans, but it has …

Cigarette smoke (CS) exposure and Candida albicans (C. albicans) infection are
epidemiological risk factors for oral diseases, such as oral leukoplakia (OLK). Smoking …

Rickettsiae actively escape from vacuoles and replicate free in the cytoplasm of host cells,
where inflammasomes survey the invading pathogens. In the present study, we investigated …

The inflammasome is composed of nucleotide-binding, oligomerization domain (NOD)-like
receptor (NLR) proteins, and leads to caspase-1 activation and subsequent secretion of the …

Background Interleukin-1β (IL-1β) is important for host resistance against Mycobacterium
tuberculosis (Mtb) infections. The response of the dendritic cell inflammasome during Mtb …

Neisseria gonorrhoeae is a common sexually transmitted pathogen that significantly impacts
female fertility, neonatal health, and transmission of HIV worldwide. N. gonorrhoeae usually …

Secretion of the proinflammatory cytokine IL-1β requires caspase-1 and Toll-like receptor
(TLR) signaling. However, Kanneganti et al.(2007) find that bacteria can use pore-forming …

Background The activation of NLRP3 inflammasome in macrophages has been proven to
play a crucial role in the development of cardiovascular diseases. THP-1 monocytes can be …