Urinary levels of tobacco-specific nitrosamine metabolites in relation to lung cancer development in two prospective cohorts of cigarette smokers

JM Yuan, WP Koh, SE Murphy, Y Fan, R Wang… - Cancer research, 2009 - AACR
(Methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) and its glucuronides (sum of which is
denoted as total NNAL) are metabolites of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone …

Urine concentrations of a tobacco-specific nitrosamine carcinogen in the US population from secondhand smoke exposure

JT Bernert, JL Pirkle, Y Xia, RB Jain, DL Ashley… - … , biomarkers & prevention, 2010 - AACR
Background: The tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-
butanone (NNK) and its reduction product in the body, 4-(methylnitrosamino)-1-(3-pyridyl)-1 …

Tobacco‐specific N‐nitrosamine exposures and cancer risk in the Shanghai cohort study: Remarkable coherence with rat tumor sites

I Stepanov, E Sebero, R Wang, YT Gao… - … journal of cancer, 2014 - Wiley Online Library
The tobacco‐specific nitrosamines N′‐nitrosonornicotine (NNN) and 4‐
(methylnitrosamino)‐1‐(3‐pyridyl)‐1‐butanone (NNK) are potent carcinogens for the rat …

Quantitation of metabolites of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone after cessation of smokeless tobacco use

SS Hecht, SG Carmella, M Ye, K Le, JA Jensen… - Cancer research, 2002 - AACR
Two major metabolites of the tobacco-specific lung carcinogen 4-(methylnitrosamino)-1-(3-
pyridyl)-1-butanone (NNK) were previously shown to be highly persistent in human urine …

Analysis of total 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) in human urine

SG Carmella, S Han, A Fristad, Y Yang… - … Biomarkers & Prevention, 2003 - AACR
A new method was developed for the analysis of metabolites of the tobacco-specific lung
carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in human urine. The …

Intraindividual and interindividual differences in metabolites of the tobacco-specific lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in smokers' …

SG Carmella, SA Akerkar, JP Richie Jr… - … , biomarkers & prevention …, 1995 - AACR
This study describes quantitation in smokers' urine of two metabolites of the tobacco-specific
lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). The metabolites are …

Differences in the urinary metabolites of the tobacco-specific lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in black and white smokers.

JP Richie Jr, SG Carmella, JE Muscat, DG Scott… - … , biomarkers & prevention …, 1997 - AACR
Incidence and mortality rates for lung cancer in the United States are significantly greater in
blacks than in whites. This disparity cannot be explained by differences in smoking behavior …

Variation in levels of the lung carcinogen NNAL and its glucuronides in the urine of cigarette smokers from five ethnic groups with differing risks for lung cancer

SL Park, SG Carmella, X Ming, E Vielguth… - … Biomarkers & Prevention, 2015 - AACR
Abstract Background: Results of the Multiethnic Cohort (MEC) study demonstrated that, for
the same quantity of cigarettes smoked, African Americans and Native Hawaiians have a …

Metabolism of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone to its biomarker total NNAL in smokeless tobacco users

SS Hecht, SG Carmella, I Stepanov, J Jensen… - … Biomarkers & Prevention, 2008 - AACR
Abstract The tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone
(NNK) is one of the most abundant carcinogens in smokeless tobacco products. NNK uptake …

Subpicogram per milliliter determination of the tobacco-specific carcinogen metabolite 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol in human urine using liquid …

P Jacob III, C Havel, DH Lee, L Yu, MD Eisner… - Analytical …, 2008 - ACS Publications
Exposure to secondhand tobacco smoke (SHS) has been linked to increased risk for a
number of diseases, including lung cancer. The tobacco-specific nitrosamine 4 …