[HTML][HTML] Clinical utility of sperm DNA fragmentation testing: practice recommendations based on clinical scenarios

A Agarwal, A Majzoub, SC Esteves, E Ko… - Translational …, 2016 - ncbi.nlm.nih.gov
Sperm DNA fragmentation (SDF) has been generally acknowledged as a valuable tool for
male fertility evaluation. While its detrimental implications on sperm function were …

[HTML][HTML] The Society for Translational Medicine: clinical practice guidelines for sperm DNA fragmentation testing in male infertility

A Agarwal, CL Cho, A Majzoub… - … andrology and urology, 2017 - ncbi.nlm.nih.gov
Sperm DNA fragmentation (SDF) testing has been emerging as a valuable tool for male
fertility evaluation. While the essential role of sperm DNA integrity in human reproduction …

An update on clinical and surgical interventions to reduce sperm DNA fragmentation in infertile men

SC Esteves, D Santi, M Simoni - Andrology, 2020 - Wiley Online Library
Background Sperm chromatin integrity is essential for normal embryo development and
pregnancy outcome. Sperm DNA fragmentation (SDF) testing constitutes a diagnostic tool to …

Sperm DNA fragmentation testing: Summary evidence and clinical practice recommendations

SC Esteves, A Zini, RM Coward, DP Evenson… - Andrologia, 2021 - Wiley Online Library
We herein summarise the evidence concerning the impact of sperm DNA fragmentation in
various clinical infertility scenarios and the advances on sperm DNA fragmentation tests …

[HTML][HTML] Sperm DNA fragmentation: a new guideline for clinicians

A Agarwal, A Majzoub, S Baskaran… - The world journal of …, 2020 - ncbi.nlm.nih.gov
Sperm DNA integrity is crucial for fertilization and development of healthy offspring. The
spermatozoon undergoes extensive molecular remodeling of its nucleus during later phases …

[HTML][HTML] What should be done for men with sperm DNA fragmentation?

GY Kim - Clinical and experimental reproductive medicine, 2018 - ncbi.nlm.nih.gov
In an age when a small quantity of sperm can lead to pregnancy through in vitro fertilization
or intracytoplasmic sperm injection, selecting healthy sperm is important. Sperm DNA …

[HTML][HTML] A systematic review on sperm DNA fragmentation in male factor infertility: laboratory assessment

MKP Selvam, A Agarwal - Arab Journal of Urology, 2018 - Elsevier
Objective To review sperm DNA fragmentation (SDF) testing as an important sperm function
test in addition to conventional semen analysis. High SDF is negatively associated with …

Sperm DNA fragmentation index as a promising predictive tool for male infertility diagnosis and treatment management–meta-analyses

D Santi, G Spaggiari, M Simoni - Reproductive biomedicine online, 2018 - Elsevier
Conventional semen analyses have limitations in male infertility diagnosis and prognosis.
Assessment of sperm DNA fragmentation (sDF) has been proposed to discriminate fertile …

Diagnostic accuracy of sperm DNA degradation index (DDSi) as a potential noninvasive biomarker to identify men with varicocele-associated infertility

SC Esteves, J Gosálvez, C López-Fernández… - … urology and nephrology, 2015 - Springer
Purpose Varicocele is a frequent cause of impaired testicular function that has been
associated with increased levels of sperm DNA fragmentation (SDF). Sperm with degraded …

European Association of Urology guidelines panel on male sexual and reproductive health: a clinical consultation guide on the indications for performing sperm DNA …

T Tharakan, C Bettocchi, J Carvalho, G Corona… - European Urology …, 2022 - Elsevier
Accumulating evidence has highlighted the contribution of oxidative stress and sperm DNA
fragmentation (SDF) in the pathophysiology of male infertility. SDF has emerged as a novel …