The role of serotonin in major depressive disorder (MDD) is the focus of accumulating
clinical and preclinical research. The results of these studies reflect the complexity of …

Major depressive disorder (MDD) is a heritable neuropsychiatric disease associated with
severe changes at cellular and molecular levels. Its diagnosis mainly relies on the …

Abstract Major Depressive Disorder (MDD) is a highly prevalent psychiatric diagnosis that is
associated with a high degree of morbidity and mortality. This debilitating disorder is …

The interaction between genes and environment plays a significant role in the pathogenesis
of major depression and mood disorders. Preclinical and clinical studies have established …

Depression is a polygenic and highly complex psychiatric disorder that remains a major
burden on society. Antidepressants, such as selective serotonin reuptake inhibitors (SSRIs) …

The monoamine hypothesis of depression posits that an imbalance in monoaminergic
neurotransmission is causally related to the clinical features of depression. Antidepressants …

Serotonin systems appear to play a key role in the pathophysiology of major depressive
disorder. Consequently, ongoing research determines whether serotonin related genes …

The neurotransmitter serotonin (5-hdroxytryptamine; 5-HT) has been implicated in the
pathophysiology and treatment of major depression since the serendipitous discovery of …

Serotonin regulates many physiological processes including sleep, appetite, and mood.
Thus, serotonergic system is an important target in the treatment of psychiatric disorders …

The serotonergic mechanisms have been successfully utilized by the majority of
antidepressant drug discovery programmes, while the search for newer targets remains …