Published studies demonstrate that significant ethnic differences can exist in the metabolism
of some drugs. These differences are caused by cytochrome P450 polymorphisms and …

CYP2D6 is a member of cytochrome P450 enzymes that metabolise over 25% of commonly
used drugs. Genetic polymorphisms can cause insufficient drug efficacy at usually …

Cytochromes are proteins that catalyze electron transfer reactions of many metabolic
pathways. They are involved in drug metabolism and thus determines the therapeutic safety …

Purpose A number of institutions have clinically implemented CYP2D6 genotyping to guide
drug prescribing. We compared implementation strategies of early adopters of CYP2D6 …

Aim: The purpose of this study was to determine the genetic polymorphisms of the CYP2D6
gene and to elucidate the allele distribution pattern in the Chinese Han population. Materials …

The Pharmacogene Variation Consortium (PharmVar) provides nomenclature for the highly
polymorphic human CYP2D6 gene locus. CYP2D6 genetic variation impacts the metabolism …

Unexplained cases of CYP2D6 genotype/phenotype discordance continue to be discovered.
In previous studies, several African Americans with a poor metabolizer phenotype carried …

The cytochrome P450 2D6 (CYP 2D6) gene locus is challenging to accurately genotype due
to numerous single nucleotide variants and complex structural variation. Our goal was to …

We investigated whether CYP2D6 extensive metabolizers carrying a nonfunctional allele
are at higher risk of phenoconversion to poor metabolizers in the presence of CYP2D6 …

Abstract CYP2C19 and CYP2D6 are important drug-metabolizing enzymes that are involved
in the metabolism of around 30% of all medications. Importantly, the corresponding genes …