AIM To evaluate effect of hypertension on retinal ganglion cell (RGC) apoptosis, intraocular
pressure (IOP), and the activation of endothelin-1 (ET-1) signaling pathway in central retinal …

Purpose To evaluate the effect of Deoxycorticoacetate (DOCA)‐salt Hypertension model on
IOP, retinal ganglion cell (RGC) apoptosis, ratio of endothelin (ET‐1)/endothelial Nitric Oxide …

Purpose To set up the Sharma's chronic intraocular hypertension model and investigate the
intraocular pressure (IOP) as well as the optic nerve damage of this model in rat. Methods …

AIM To explore the injury of retinal ganglion cells (RGCs) and optic nerves in acute ocular
hypertension (OHT) rats. METHODS We retrogradely labeled RGCs and optic nerves of …

Objective The objective of this work was to find out the effects of nuclear factor erythroid 2-
related factor/heme oxygenase-1 (Nrf2/HO-1) pathway on retinal ganglion cell (RGC) injury …

The purpose of this study was to design an animal model mimicking glaucoma with
hemodynamic instability and to identify involvement of angiotensin II (AngII) and associated …

ET1 induced retinal and optic nerve injury is widely used as an experimental model to study
unexplained pathophysiology and therapeutic targets involved in several ophthalmic …

Purpose. Diabetes mellitus (DM) is a risk factor for open-angle glaucoma, although the
mechanistic interrelationship of the two is debatable. The purpose of this study is to test …

Abstract This study aimed to modify a chronic ocular hypertension (OHT) rat model to screen
for potential compounds to protect retinal ganglion cells (RGCs) from responding to …

Aim: To investigate the effect of vascular endothelial growth factor (VEGF) on the expression
of pigment epithelium-derived factor (PEDF) in retina and the protective effect of VEGF on …