Background Diabetic retinopathy and retinal vein occlusion are vision threatening retinal
vascular diseases. Current first-line therapy targets the vascular component, but many …

Purpose: To quantitatively characterize macrophage-like cells (MLCs) at the vitreoretinal
interface in different severity stages of diabetic retinopathy (DR) using optical coherence …

The identity of vitreoretinal interface macrophage-like cells (MLCs) remains unknown and
potential candidates include retinal microglia, perivascular macrophages, monocyte-derived …

Aims/hypothesis Diabetic retinopathy is characterised by neuroinflammation that drives
neuronal and vascular degenerative pathology, which in many individuals can lead to retinal …

Abstract Background Microglia/macrophages (MG/MΦ) are found in the subretinal space in
both mice and humans. Our goal was to study the spatial and temporal distribution, the …

Purpose: To image retinal macrophages at the vitreoretinal interface in the living human
retina using a clinical optical coherence tomography (OCT) device. Methods: Eighteen …

Purpose To evaluate whether anti-vascular endothelial growth factor (VEGF) neutralizing
antibodies injected in the vitreous of rat eyes influence retinal microglia and macrophage …

Macrophage-like cells (MLCs) are potential inflammatory biomarkers. We previously showed
that MLCs are increased in proliferative diabetic retinopathy (PDR) eyes. Vision-threatening …

The recent paradigm shift that microglia are yolk sac-derived, not hematopoietic-derived, is
reshaping our knowledge about the isolated role of microglia in CNS diseases, including …

Background Activation of resident microglia accompanies every known form of
neurodegeneration, but the involvement of peripheral monocytes that extravasate and …