The association of elevated level of cyclic guanosine monophosphate (cGMP) with inhibition
of hyperalgesia and involvement of nitric oxide (NO)-cGMP pathway in the modulation of …

Although several lines of evidence have shown a role of the nitric oxide/cyclic guanosine
monophosphate signaling pathway in the nociceptive mechanism, the exact role of the …

Persistent stimulation of nociceptors and C-fibers by tissue injury causes hyperalgesia and
allodynia by sensitization of nociceptors and facilitation of synaptic transmission in the spinal …

Nitric oxide has been proven to play an important role in nociception, accordingly, its
promoters, phosphodiesterase inhibitors have been investigated as pain response …

Experimental studies have indicated the importance of cAMP and cGMP in modulation of
peripheral sensory neurons leading to hyperalgesic response. The concentration of both …

In this study, we aimed to investigate the peripheral antinociception effects of specific
phosphodiesterase 5 (PDE-5) inhibitor vardenafil on carrageenan-induced nociception in …

Various evidence has demonstrated a role of the nitric oxide (NO)/cGMP signaling pathway
in the processing of nociception. The exact role of phosphodiesterase-5 (PDE-5) via the …

Introduction New therapeutic alternatives for pain relief include the use of
phosphodiesterase-5 (PDE5) inhibitors, which could prevent the transmission of painful …

Acetylcholine and cholinomimetic agents with predominant muscarinic action are known to
increase the concentration of cGMP by activation of nitric oxide signaling pathway in the …

Peripheral activation of the NO-cGMP pathway has been implicated in various nociceptive
conditions. The antinociceptive effect of the PDE-5 inhibitor, sildenafil, alone or in …