Distinct hyperpolarizing and relaxant roles for gap junctions and endothelium-derived H2O2 in NO-independent relaxations of rabbit arteries

AT Chaytor, DH Edwards… - Proceedings of the …, 2003 - National Acad Sciences
We have compared the contributions of gap junctional communication and chemical
signaling via H2O2 to NO-independent relaxations evoked by the Ca2+ ionophore A23187 …

Role of heterocellular Gap junctional communication in endothelium-dependent smooth muscle hyperpolarization: inhibition by a connexin-mimetic peptide

KA Dora, PEM Martin, AT Chaytor, WH Evans… - Biochemical and …, 1999 - Elsevier
A synthetic connexin-mimetic peptide (Gap 27 peptide) was used to evaluate the
contribution of gap junctional communication to smooth muscle responses mediated by the …

Relative contributions of NO and gap junctional communication to endothelium-dependent relaxations of rabbit resistance arteries vary with vessel size

RS Berman, PEM Martin, WH Evans, TM Griffith - Microvascular research, 2002 - Elsevier
Two synthetic peptide inhibitors of gap junctional communication have been used to
compare the contribution of direct cell–cell coupling to acetylcholine-induced relaxations of …

Central role of heterocellular gap junctional communication in endothelium‐dependent relaxations of rabbit arteries

AT Chaytor, WH Evans, TM Griffith - The Journal of physiology, 1998 - Wiley Online Library
1 The contribution of gap junctions to endothelium‐dependent relaxation was investigated in
isolated rabbit conduit artery preparations pre‐constricted by 10 μM phenylephrine (PhE). 2 …

Nitric oxide–independent relaxations to acetylcholine and A23187 involve different routes of heterocellular communication: role of gap junctions and phospholipase …

IR Hutcheson, AT Chaytor, WH Evans… - Circulation …, 1999 - Am Heart Assoc
NO-and prostanoid-independent relaxations are generally assumed to be mediated by an
endothelium-derived hyperpolarizing factor (EDHF) that has been postulated to be an …

Endothelium‐dependent smooth muscle hyperpolarization: do gap junctions provide a unifying hypothesis?

TM Griffith - British journal of pharmacology, 2004 - Wiley Online Library
An endothelium‐derived hyperpolarizing factor (EDHF) that is distinct from nitric oxide (NO)
and prostanoids has been widely hypothesized to hyperpolarize and relax vascular smooth …

Gap junction-dependent increases in smooth muscle cAMP underpin the EDHF phenomenon in rabbit arteries

HJ Taylor, AT Chaytor, DH Edwards… - … and biophysical research …, 2001 - Elsevier
We have investigated the role of cAMP in nitric oxide (NO)-and prostanoid-independent
vascular relaxations evoked by acetylcholine (ACh) in isolated arteries and perfused ear …

cAMP facilitates EDHF-type relaxations in conduit arteries by enhancing electrotonic conduction via gap junctions

TM Griffith, AT Chaytor, HJ Taylor… - Proceedings of the …, 2002 - National Acad Sciences
We have investigated the role of cAMP in NO-and prostanoid-independent relaxations that
are widely attributed to an endothelium-derived hyperpolarizing factor (EDHF). Under …

The obligatory link: role of gap junctional communication in endothelium-dependent smooth muscle hyperpolarization

TM Griffith, AT Chaytor, DH Edwards - Pharmacological research, 2004 - Elsevier
Although an endothelium-derived hyperpolarizing factor (EDHF) has often been
hypothesized to underpin vascular relaxations that are independent of nitric oxide (NO) and …

Endothelial alkalinisation inhibits gap junction communication and endothelium‐derived hyperpolarisations in mouse mesenteric arteries

E Boedtkjer, S Kim, C Aalkjaer - The Journal of Physiology, 2013 - Wiley Online Library
Key points Gap junctions are important for coordination and transfer of signals between
cells. Signals initiated in the vascular endothelium can spread through myoendothelial gap …