Thyroid hormone synthesis and secretion is regulated by a classic feedback loop system.
The hypothalamus, through the release of thyrotropinreleasing hormone (TRH), stimulates …

The liver plays a major role in modifying the total circulating hormone concentrations of
thyroxine and triiodo-thyronme by secretion and degradation of carrier proteins. It also is a …

The liver plays a dominant role in the metabolism of the thyroidal hormones; it is here that
the 5'deiodase acts to convert part of T4 to T3. There are eight further circulating …

Thyroxine and tri‐iodothyronine are essential for normal organ growth, development and
function. These hormones regulate the basal metabolic rate of all cells, including …

The liver is the major site of the peripheral metabolism of thyroid hormones and is involved
in conjugation, biliary execretion, oxidative deamination, and extrathyroidal deiodination of …

There is a recent hypothesis that thyroxine (T4), secreted by the thyroid gland under
physiological conditions, is mono-deiodinated in extrathyroidal sites to form the more active …

Possible arterio-venous gradients of T4, T3, rT3 and 3, 3′-diiodothyronine (3, 3′-T2)
across the liver and the kidneys were measured in 9 patients with varying degrees of liver …

One if not the most important reason to study thy· roid hormone metabolism is the notion that
most (in humans about 80%) of the overall 3, 3', 5· triiodo--thyronine (T3) production is …

Publisher Summary Thyroid hormone synthesis occurs within the follicles of the thyroid
gland. This chapter describes the following steps involved in thyroid hormone synthesis:(1) …

An investigation has been made into the exchange of thyroxine between human plasma and
the perfused rat liver. A stop-flow method was used to hold plasma within the liver sinusoids …