This study was undertaken to evaluate the effect of altered thyroid states on hepatic T3
production in a functioning intact organ system, the isolated perfused liver …

Thyroid hormones (THs) play critical roles in growth, differentiation and metabolism. They
are important for optimal functioning of almost all tissues with major effects on metabolic rate …

Administration of phenobarbital to rats in a dosage schedule previously demonstrated to
increase hepatocellular binding of thyroxine results in increased hormonal turnover, due …

We studied serum concentrations of thyroid hormones and thyrotropin (TSH) in 23 clinically
euthyroid patients with hepatic cirrhosis. The mean serum total thyroxine T4 concentration of …

The concept of “hormone,” implying purely information-carrying functions, may obscure
rather than clarify the mechanism of action of iodothyronines. No single set of cellular control …

Iodinated thyroglobulin stored in the thyroid follicular lumen is subjected to an internalization
process and thought to be transferred into the lysosomal compartment for proteolytic …

Recent developments in thyroid hormone metabolism have helped to understand the
complex events which characterize the regulation of TSH secretion. Plasma T3 …

S TUDIES of the thyroid hormones (Fig. 1) continue to provide new insights into the
molecular level events controlling biosynthesis, transport, and mechanism of action. Despite …

In order to improve understanding of factors that may contribute to reduced serum T4 in non-
thyroidal illnesses, we have studied baseline thyroid function, serum TSH response to …