Background Obesity induced brain inflammation is associated with cognitive disorders. We
aimed to investigate the influence of vitamin D on hypothalamus and hippocampus …

This current study aimed to elucidate the effects and possible underlying mechanisms of
long-term supplementation with dietary luteolin (LU)-enriched artichoke leaf (AR) in high-fat …

Background: Two brown-like adipocytes, including classical brown adipocytes from brown
adipose tissues and beige cells from white adipose tissues, regulate thermogenesis. The …

Apolipoprotein E4 (ApoE4), one of three common isoforms of ApoE, is a major risk factor for
late-onset Alzheimer disease (AD). ApoE-deficient mice, as well as mice expressing human …

This study evaluated the effects of omega-3 on inflammation, oxidative stress, and energy
metabolism parameters in the brain of mice subjected to high-fat diet-induced obesity model …

Purpose: Luteolin exerts beneficial effects against obesity-associated comorbidities,
although its influence on vascular dysfunction remains undetermined. We examined the …

Background Hypothalamic inflammation including astrogliosis and microglia activation
occurs after intake of high fat diet (HFD) in rodent models or in obese individuals. However …

The epidemic and experimental studies have confirmed that the obesity induced by high-fat
diet not only caused neuronal insulin resistance, but also induced brain mitochondrial …

AIM: To investigate the therapeutic effects of lutein against non-alcoholic fatty liver disease
(NAFLD) and the related underlying mechanism. METHODS: After 9 d of acclimation to a …

Obesity arising from excessive dietary fat intake is a risk factor for cognitive decline,
dementia and neurodegenerative diseases, including Alzheimer's disease. Here, we studied …