Ameliorating effect of luteolin on memory impairment in an Alzheimer's disease model

H Wang, H Wang, H Cheng… - Molecular medicine …, 2016 - spandidos-publications.com
Alzheimer's disease (AD) is one of the most prevalent neurodegenerative disorder. It is
characterized by the formation of amyloid plaques and neurofibrillary tangles in the brain …

EGCG ameliorates high‐fat–and high‐fructose‐induced cognitive defects by regulating the IRS/AKT and ERK/CREB/BDNF signaling pathways in the CNS

Y Mi, G Qi, R Fan, Q Qiao, Y Sun, Y Gao… - The FASEB …, 2017 - Wiley Online Library
Obesity, which is caused by an energy imbalance between calorie intake and consumption,
has become a major international health burden. Obesity increases the risk of insulin …

Curdlan prevents the cognitive deficits induced by a high-fat diet in mice via the gut-brain axis

X Yang, M Zheng, S Hao, H Shi, D Lin… - Frontiers in …, 2020 - frontiersin.org
A high-fat (HF) diet is a major predisposing factor of neuroinflammation and cognitive
deficits. Recently, changes in the gut microbiota have been associated with …

Thymol improves high-fat diet-induced cognitive deficits in mice via ameliorating brain insulin resistance and upregulating NRF2/HO-1 pathway

FangFang, H Li, T Qin, M Li, S Ma - Metabolic brain disease, 2017 - Springer
Abstracts The impaired insulin signaling has been recognized as a common pathogenetic
mechanism between diabetes and Alzheimer's disease (AD). In the progression of AD, brain …

Luteolin targets the toll-like receptor signaling pathway in prevention of hepatic and adipocyte fibrosis and insulin resistance in diet-induced obese mice

EY Kwon, MS Choi - Nutrients, 2018 - mdpi.com
This study was to investigate the protective role of luteolin on inflammation-mediated
metabolic diseases, focusing on the role of luteolin in the modulation of the Toll-like receptor …

Chamomile decoction mitigates high fat diet-induced anxiety-like behavior, neuroinflammation and cerebral ROS overload

MA Jabri, K Rtibi, H Sebai - Nutritional Neuroscience, 2022 - Taylor & Francis
An abundant literature suggests that obesity-associated with taking a high fat diet is related
to an elevated risk of type 2 diabetes and metabolic syndrome. However, metabolic …

Metabolic stress alters antioxidant systems, suppresses the adiponectin receptor 1 and induces Alzheimer's like pathology in mice brain

JR Hahm, MH Jo, R Ullah, MW Kim, MO Kim - Cells, 2020 - mdpi.com
Oxidative stress and insulin resistance play major roles in numerous neurodegenerative
diseases, including Alzheimer's disease (AD). A high-fat diet induces obesity-associated …

Allicin ameliorates obesity comorbid depressive-like behaviors: involvement of the oxidative stress, mitochondrial function, autophagy, insulin resistance and NOX …

W Gao, W Wang, J Zhang, P Deng, J Hu, J Yang… - Metabolic brain …, 2019 - Springer
The increased prevalence of obesity has been a major medical and public health problem in
the past decades. In obese status, insulin resistance and sustained oxidative stress damage …

Oxidative stress-induced cognitive impairment in obesity can be reversed by vitamin D administration in rats

G Hajiluian, M Abbasalizad Farhangi… - Nutritional …, 2018 - Taylor & Francis
Background: There is evidence that obesity leads to cognitive impairments via several
markers of oxidative stress including glutathione peroxidase (GPx), superoxide dismutase …

Cognitive impairment following high fat diet consumption is associated with brain inflammation

PJ Pistell, CD Morrison, S Gupta, AG Knight… - Journal of …, 2010 - Elsevier
C57Bl/6 mice were administered a high fat, Western diet (WD, 41% fat) or a very high fat lard
diet (HFL, 60% fat), and evaluated for cognitive ability using the Stone T-maze and for …