Phage therapy in the twenty-first century: facing the decline of the antibiotic era; is it finally time for the age of the phage?

S Hesse, S Adhya - Annual review of microbiology, 2019 - annualreviews.org
Burgeoning problems of antimicrobial resistance dictate that new solutions be developed to
combat old foes. Use of lytic bacteriophages (phages) for the treatment of drug-resistant …

Translating phage therapy into the clinic: recent accomplishments but continuing challenges

A Petrovic Fabijan, J Iredell, K Danis-Wlodarczyk… - Plos …, 2023 - journals.plos.org
Phage therapy is a medical form of biological control of bacterial infections, one that uses
naturally occurring viruses, called bacteriophages or phages, as antibacterial agents …

Current clinical landscape and global potential of bacteriophage therapy

NM Hitchcock, D Devequi Gomes Nunes, J Shiach… - Viruses, 2023 - mdpi.com
In response to the global spread of antimicrobial resistance, there is an increased demand
for novel and innovative antimicrobials. Bacteriophages have been known for their potential …

Phage therapy for antibiotic-resistant bacterial infections

GF Hatfull, RM Dedrick… - Annual review of medicine, 2022 - annualreviews.org
Antibiotic resistance in bacterial pathogens presents a substantial threat to the control of
infectious diseases. Development of new classes of antibiotics has slowed in recent years …

Phage therapy in the 21st century: is there modern, clinical evidence of phage-mediated efficacy?

ST Abedon, KM Danis-Wlodarczyk, DR Alves - Pharmaceuticals, 2021 - mdpi.com
Many bacteriophages are obligate killers of bacteria. That this property could be medically
useful was first recognized over one hundred years ago, with 2021 being the 100-year …

[HTML][HTML] Phage therapy: a renewed approach to combat antibiotic-resistant bacteria

KE Kortright, BK Chan, JL Koff, PE Turner - Cell host & microbe, 2019 - cell.com
Phage therapy, long overshadowed by chemical antibiotics, is garnering renewed interest in
Western medicine. This stems from the rise in frequency of multi-drug-resistant bacterial …

Phage therapy

JN Housby, NH Mann - Drug discovery today, 2009 - Elsevier
There is a renaissance of interest in the antimicrobial potential of phages as more
pathogens become multiply antibiotic resistant. Phage therapy is not a new concept, and it is …

[PDF][PDF] Phage therapy: From biological mechanisms to future directions

SA Strathdee, GF Hatfull, VK Mutalik, RT Schooley - Cell, 2023 - cell.com
Increasing antimicrobial resistance rates have revitalized bacteriophage (phage) research,
the natural predators of bacteria discovered over 100 years ago. In order to use phages …

Bacteriophages as alternatives to antibiotics in clinical care

D Romero-Calle, R Guimarães Benevides… - Antibiotics, 2019 - mdpi.com
Antimicrobial resistance is increasing despite new treatments being employed. With a
decrease in the discovery rate of novel antibiotics, this threatens to take humankind back to …

Phage therapy in the postantibiotic era

FL Gordillo Altamirano, JJ Barr - Clinical microbiology reviews, 2019 - Am Soc Microbiol
Antibiotic resistance is arguably the biggest current threat to global health. An increasing
number of infections are becoming harder or almost impossible to treat, carrying high …