Autoimmune diseases are burdensome conditions that affect a significant fraction of the
global population. The hallmark of autoimmune disease is a host's immune system being …

Autoimmune diseases are a diverse and complex set of chronic disorders with a substantial
impact on patient quality of life and a significant global healthcare burden. Current …

In the past few decades, biological drugs and small molecule inhibitors targeting
inflammatory cytokines, immune cells, and intracellular kinases have become the standard …

Autoimmune disease, caused by unwanted immune responses to self-antigens, affects
millions of people each year and poses a great social and economic burden to individuals …

Many biologic agents that were first approved for the treatment of malignancies are now
being actively investigated and used in a variety of autoimmune diseases such as …

Standard treatments for autoimmune and autoinflammatory disorders rely mainly on
immunosuppression. These are predominantly symptomatic remedies that do not affect the …

Autoimmune diseases are heterogeneous group of disorders that together represent an
enormous societal and medical problem. CD4+ T cells have critical roles in the initiation and …

Current treatment options for autoimmune disease (AID) are essentially
immunosuppressive, inhibiting the inflammatory cascade, without curing the disease …

The main goal of antigen-specific immunotherapy (ASI) in autoimmune and rheumatic
diseases is to reprogramme or remove autoreactive cells and/or induce immune tolerance to …

The induction and maintenance of immune tolerance represent major therapeutic goals in
autoimmunity. Current strategies for controlling autoimmune disorders are based on the …