Background Neural tube defects (NTDs) are very common and severe birth defects that are
caused by failure of neural tube closure and that have a complex aetiology. Anencephaly …

Neural tube defects (NTDs) affecting the brain (anencephaly) are lethal before or at birth,
whereas lower spinal defects (spina bifida) may lead to lifelong neurological handicap …

Purpose Neural tube defects are a group of birth defects caused by failure of neural tube
closure during development. The etiology of NTD, requiring a complex interaction between …

Background Neural tube defects (NTD) are among the most common defects affecting 1:
1000 births. They are caused by a failure of neural tube closure during development. Their …

Abstract Background Neural tube defects (NTDs) are failure of neural tube closure, which
includes multiple central nervous system phenotypes. More than 300 mouse mutant strains …

Neural tube defects (NTDs) are common, often severe congenital malformations of the
central nervous system. Anencephaly and open spina bifida (myelomeningocele) arise from …

Neural tube defects (NTDs), which include spina bifida and anencephaly, are the second
most common form of human structural congenital malformations. While it is well established …

Neural tube defects (NTDs) are common birth defects of complex etiology. Family and
population-based studies have confirmed a genetic component to NTDs. However, despite …

The formation of the embryonic brain and spinal cord begins as the neural plate bends to
form the neural folds, which meet and adhere to close the neural tube. The neural ectoderm …

Spina bifida, anencephaly, and encephalocele are commonly grouped together and termed
neural tube defects (NTD). Failure of closure of the neural tube during development results …