Abstract Hypoxia-inducible factor-1α (HIF-1α) is a master transcription factor that is critical for
the regulation of a variety of cellular functions. HIF-1α is rapidly degraded under normoxic …

Hypoxia and induction of hypoxia-inducible factors (HIF-1α and HIF-2α) is a hallmark of
many tumors. Under normal oxygen tension HIF-alpha subunits are rapidly degraded …

Hypoxia inducible factor-1 (HIF-1) is the main transcriptional factor activated by hypoxia.
Besides the well-described role assigned to HIF-1 in the adaptation of cells to hypoxia …

Stabilization of the hypoxia-inducible factor-1 (HIF-1) protein is essential for its role as a
regulator of gene expression under low oxygen conditions. Here, employing a novel …

The hypoxia-inducible factor-1α (HIF-1α) is a master regulator of the cellular response to
decreased oxygen levels. This transcription factor is highly unstable at normal oxygen …

Under hypoxia, HIF-1α binds to aryl hydrocarbon receptor nuclear translocator (ARNT, also
called HIF-1β) to activate expression of genes important for cell survival. Alternatively, HIF …

The hypoxia-inducible factor 1α (HIF-1α), a member of the PAS superfamily, is a global
regulator of cellular and systemic O2 homeostasis as well as embryonic development. As …

The hypoxia-inducible factor 1 transcriptional activator complex (HIF-1) is involved in the
activation of the erythropoietin and several other hypoxia-responsive genes. The HIF-1 …

Hypoxia-inducible factor-1α (HIF-1α) 1 is a global transcriptional regulator of the hypoxic
response. Under normoxic conditions, HIF-1α is recognized by the von Hippel-Lindau tumor …

Hypoxia inducible factor 1 (HIF-1), a heterodimeric transcription factor composed of HIF-1α
and HIF-1β subunits, serves as a key regulator of metabolic adaptation to hypoxia. The …