Hypoxia-inducible factors (HIFs) are heterodimeric oxygen-sensitive basic helix-loop-helix
transcription factors that play central roles in cellular adaptation to low oxygen environments …

The transcriptional factor hypoxia‐inducible factor‐1 (HIF‐1) plays an important role in solid
tumor cell growth and survival. Overexpression of HIF‐1α has been demonstrated in many …

Mechanisms regulating protein degradation ensure the correct and timely expression of
transcription factors such as hypoxia inducible factor (HIF). Under normal O2 tension, HIFα …

Hypoxia-inducible factor-1 (HIF-1) is a transcriptional activator involved in adaptation to
hypoxic stress. Previous studies from our laboratory demonstrated that pharmacological …

Hypoxia-inducible factor HIF-1 is responsible for radiation resistance and poor prognosis in
cancer therapy. As part of our drug discovery program, a novel HIF inhibitor, LW6, was …

In the present study, the role of the C-terminal α-helical domain (amino acid (aa) 195–208)
of the von Hippel–Lindau (VHL) tumour suppressor was investigated. Deletions of the VHL …

Abstract Hypoxia-inducible factor-1α (HIF-1α) protein is degraded under normoxia by its
association to von Hippel-Lindau protein (pVHL) and further proteasomal digestion …

An important regulator involved in oxygen-dependent gene expression is the transcription
factor HIF (hypoxia-inducible factor), which is composed of an oxygen-sensitive α-subunit …

HIF-1α is a normally labile proangiogenic transcription factor that is stabilized and activated
in hypoxia. Although the von Hippel Lindau (VHL) gene product, the ubiquitin ligase …

Abstract Hypoxia-inducible factor-1α (HIF-1α) is a master transcriptional regulator of cellular
response to hypoxia. In normoxia, HIF-1α is degraded through the prolyl hydroxylase (PHD) …