Complex circulatory and respiratory systems are established during embryonic development
and used in fetal and postnatal life to ensure oxygen delivery to every cell in the human …

It is becoming increasingly evident that the degradation of nuclear proteins requires nuclear-
cytoplasmic trafficking of both the substrate proteins, as well as the E3 ubiquitin-ligases …

The ubiquitin-proteasome pathway (UPP) is involved in regulation of multiple cellular
processes. Hypoxia-inducible factor 1α (HIF-1α) is a prototypic target of the UPP and, as …

Adaptation to hypoxia is primarily mediated by the hypoxia-inducible transcription factor,
HIF. The regulation of HIF activity by the oxygen-dependent degradation of the HIF-1α and …

In hypoxic cells, HIF-1alpha escapes from oxygen-dependent proteolysis and binds to the
hypoxia-responsive element (HRE) for transcriptional activation of target genes involved in …

Hypoxia-inducible factor (HIF) is a heterodimeric transcription factor induced by hypoxia.
Under normoxic conditions, site-specific proline hydroxylation of the α subunits of HIF allows …

A classical cellular response to hypoxia is a cessation of growth. Hypoxia-induced growth
arrest differs in different cell types but is likely an essential aspect of the response to …

HIF-1α not only enables cells to survive under hypoxic conditions but also promotes cell
cycle arrest and apoptosis. Therefore, its expression should be controlled at optimal levels in …

Abstract Hypoxia-inducible factor-1α (HIF-1α) plays central roles in the hypoxia response. It
is highly expressed in multiple cancers, but not always correlated with hypoxia. Mutation of …

Hypoxia-inducible factor (HIF) is a heterodimeric transcription factor that is composed of a
hypoxia-inducible α subunit (HIF-1α and HIF-2α) and a constitutively expressed β subunit …