Complex regulation of capsaicin on intracellular second messengers by calcium dependent and independent mechanisms in primary sensory neurons
Intracellular second messengers play an important role in capsaicin-and analogous-induced
sensitization and desensitization in pain. Fluorescence Ca2+ imaging, enzyme …
sensitization and desensitization in pain. Fluorescence Ca2+ imaging, enzyme …
Intracellular ATP increases capsaicin-activated channel activity by interacting with nucleotide-binding domains
J Kwak, MH Wang, SW Hwang, TY Kim… - Journal of …, 2000 - Soc Neuroscience
Capsaicin (CAP)-activated ion channel plays a key role in generating nociceptive neural
signals in sensory neurons. Here we present evidence that intracellular ATP upregulates the …
signals in sensory neurons. Here we present evidence that intracellular ATP upregulates the …
Inhibitory effects of capsaicin on voltage-gated potassium channels by TRPV1-independent pathway
R Yang, Z Xiong, C Liu, L Liu - Cellular and molecular neurobiology, 2014 - Springer
Previously we observed that capsaicin, a transient receptor potential vanilloid 1 (TRPV1)
receptor activator, inhibited transient potassium current (IA) in capsaicin-sensitive and …
receptor activator, inhibited transient potassium current (IA) in capsaicin-sensitive and …
The cAMP-dependent kinase pathway does not sensitize the cloned vanilloid receptor type 1 expressed in xenopus oocytes or Aplysia neurons
Capsaicin-activated channels present in sensory neurons are ligand-gated cation channels
that largely account for mediating some types of pain. The cAMP-dependent protein kinase …
that largely account for mediating some types of pain. The cAMP-dependent protein kinase …
Population Coding of Capsaicin Concentration by Sensory Neurons Revealed Using Ca2+ Imaging of Dorsal Root Ganglia Explants from Adult pirt-GCaMP3 Mouse.
GW Lawrence, TH Zurawski, X Dong… - Cellular Physiology & …, 2021 - search.ebscohost.com
Abstract Background/Aims: Nociceptors detect noxious capsaicin (CAPS) via the transient
receptor potential vanilloid 1 (TRPV1) ion channel, but coding mechanisms for relaying …
receptor potential vanilloid 1 (TRPV1) ion channel, but coding mechanisms for relaying …
[HTML][HTML] Mechanism of capsaicin receptor TRPV1-mediated toxicity in pain-sensing neurons focusing on the effects of Na+/Ca2+ fluxes and the Ca2+-binding protein …
L Pecze, W Blum, B Schwaller - … et Biophysica Acta (BBA)-Molecular Cell …, 2013 - Elsevier
Transient receptor potential vanilloid subtype 1 (TRPV1) receptor is a pain-sensing, ligand-
gated, non-selective cation channel expressed in peripheral sensory neurons. Prolonged …
gated, non-selective cation channel expressed in peripheral sensory neurons. Prolonged …
Modulation of intracellular calcium influences capsaicin‐induced currents of TRPV‐1and voltage‐activated channel currents in nociceptive neurones
T Hagenacker, D Büsselberg - Journal of the Peripheral …, 2007 - Wiley Online Library
Modulation of intracellular calcium ([Ca2+] i) has a major impact on processing of
nociceptive signals. While activation of the transient receptor potential vanilloid‐1 (TRPV‐1) …
nociceptive signals. While activation of the transient receptor potential vanilloid‐1 (TRPV‐1) …
[HTML][HTML] Fight fire with fire: Neurobiology of capsaicin-induced analgesia for chronic pain
Capsaicin, the pungent ingredient in chili peppers, produces intense burning pain in
humans. Capsaicin selectively activates the transient receptor potential vanilloid 1 (TRPV1) …
humans. Capsaicin selectively activates the transient receptor potential vanilloid 1 (TRPV1) …
[HTML][HTML] Tris-hydroxymethyl-aminomethane enhances capsaicin-induced intracellular Ca2+ influx through transient receptor potential V1 (TRPV1) channels
S Murakami, Y Sudo, K Miyano, H Nishimura… - Journal of …, 2016 - Elsevier
Non-selective transient receptor potential vanilloid (TRPV) cation channels are activated by
various insults, including exposure to heat, acidity, and the compound capsaicin, resulting in …
various insults, including exposure to heat, acidity, and the compound capsaicin, resulting in …
Capsaicin inhibits activation of voltage-gated sodium currents in capsaicin-sensitive trigeminal ganglion neurons
L Liu, M Oortgiesen, L Li… - Journal of …, 2001 - journals.physiology.org
Capsaicin, the pungent ingredient in hot pepper, activates nociceptors to produce pain and
inflammation. However, repeated exposures of capsaicin will cause desensitization to …
inflammation. However, repeated exposures of capsaicin will cause desensitization to …