The transient receptor potential channel subtypes V1 (TRPV1) and A1 (TRPA1) play a
critical role in the development of hyperalgesia in inflammatory pain models. Although …

The cloned capsaicin receptor, also known as vanilloid receptor subtype 1 (VR1) receptor,
has been demonstrated to be an integral membrane protein with homology to a family of …

Capsaicin (1 μM) evoked [Ca2+] i transients in two-thirds of a Percoll-gradient enriched
population of rat dorsal root ganglion (DRG) neurones. Amongst the capsaicin-sensitive …

The capsaicin receptor transient receptor potential cation channel vanilloid 1 (TRPV1) is
activated by various noxious stimuli, and the stimuli are converted into electrical signals in …

It is discussed whether capsaicin, an agonist of the pain mediating TRPV1 receptor,
decreases or increases voltage-activated calcium channel (VACC) currents (ICa (V)). ICa (V) …

Neuropeptides released from axons of primary afferent nociceptive neurons are the key
elements for the incidence of neurogenic inflammation and their release is associated with …

THE function of primary afferent neurons is to receive and transmit information from the
internal and external environment and thereby contribute to the organism's ability to …

Capsaicin is the most predominant and naturally occurring alkamide found in Capsicum
fruits. Since its discovery in the 19th century, the therapeutic roles of capsaicin have been …

Proinflammatory prostaglandin E2 is known to sensitize sensory neurons to noxious stimuli.
This sensitization is mediated by the cAMP-dependent protein kinase (PKA) signal pathway …

Changes in tonicity in the peripheral nervous system can activate nociceptors and produce
pain. Under local inflammatory conditions the peripheral terminals of nociceptors are subject …