Gadolinium (Gd) is one of trace rare earth elements (REEs) existing in human bones;
however, the underlying mechanisms of Gd element on positive cell response and bone …

Background Fabrication of porous scaffolds with great biocompatibility and osteoinductivity
to promote bone defect healing has attracted extensive attention. Methods In a previous …

Chitosan (CTS) and mesoporous calcium silicate (MCS) have been developed for bone
defect healing; however, their bone regeneration capacity still does not satisfy the patients …

Background Biomaterial-induced osteogenesis is mainly related to hierarchically porous
structures and bioactive components. Rare earth elements are well known to promote …

Systemic administration of gallium (Ga) nitrate and strontium (Sr) ranelate, which are metal
ion-based drugs, has been approved to treat the diseases associated with accelerated bone …

A coordinated interaction between osteogenesis and the osteoimmune microenvironment
plays a vital role in regulating bone healing. However, disturbances in the pro-and anti …

Natural polysaccharide (NPH)-based injectable hydrogels have shown great potential for
critical-sized bone defect repair. However, their osteogenic, angiogenic, and mechanical …

Europium-doped Gd2O3 nanotubes (Gd2O3: Eu3+ NTs) have been extensively applied in
the field of bioscience for their photostability and magnetic properties. Nevertheless, the …

Rare earth elements (REEs) generally accumulate in natural bone; however, their enhanced
effects on stem cell osteogenic differentiation and macrophage phagocytic activity remain to …

Synthetic scaffolds with multifunctional properties, including angiogenesis and osteogenesis
capacities, play an essential role in accelerating bone regeneration. In this study, various …