Objectives: Our aim was to establish whether the efficacy of post-conditioning is maintained
in aging hearts. Background: Post-conditioning, or relief of myocardial ischemia in a …

OBJECTIVES We tested the hypothesis that cardioprotection with ischemic preconditioning
(PC) is lost in the aging, or senescent, heart. BACKGROUND Although infarct size reduction …

Multiple brief periods of ischemia in the mammalian heart elicits protection against
morphologic and functional damage caused by longer-duration ischemia. Preconditioning …

Background Although both clinical and animal studies have shown that ischemic tolerance
is reduced in the senescent myocardium, it has not been clarified when myocardium …

Ischemic preconditioning (IP) reduces infarct size in young animals; however, its impact on
aging is underinvestigated. The effect of variations in IP stimuli was studied in young, middle …

Emerging evidence suggests that restoration of blood flow in a stuttering manner may limit
lethal myocardial ischemia-reperfusion injury. However, the mechanisms contributing to this …

We determined whether ischemic preconditioning could reduce infarct size and improve
cardiac function in both aging normotensive Wistar–Kyoto rats (WKY) and spontaneously …

The goal of this study was to determine if an ischemic preconditioning (IPC) protocol
improved post–ischemic functional recovery of female mouse hearts. A previous study found …

Objectives: Brief episodes of ischemia and reperfusion after a lethal ischemic insult confer
cardioprotection, a phenomenon termed “ischemic postconditioning.” However, all studies …

Background—Reperfusion during acute myocardial infarction remains the best treatment for
reducing infarct size. Postconditioning, applied at the onset of reperfusion, reduces …