Hyaluronan is a high-molecular mass component of pulmonary extracelluar matrix, and lung
injury can generate a low-molecular mass hyaluronan (HA) fragment that functions as …

Ozone is a common urban environmental air pollutant and significantly contributes to
hospitalizations for respiratory illness. The mechanisms, which regulate ozone-induced …

Ozone exposure is associated with exacerbation of reactive airways disease. We have
previously reported that the damage-associated molecular pattern, hyaluronan, is required …

Rationale: Ozone is a common environmental air pollutant that contributes to
hospitalizations for respiratory illness. The mechanisms, which regulate ozone-induced …

In this article, we provided immunological, histological, and physiological evidence that
hyaluronan mediates the development of inflammation and airway hyperresponsiveness …

Mechanisms that regulate host defense after noninfectious tissue injury are incompletely
understood. Our laboratory is interested in the role of the extracellular matrix …

Hyaluronan is a hygroscopic glycosaminoglycan that contributes to both extracellular and
pericellular matrices. While the production of hyaluronan is essential for mammalian …

Chronic obstructive pulmonary disease (COPD) is characterized by infiltration of
inflammatory cells, destruction of lung parenchyma, and airway wall remodeling …

Chlorine (Cl2) inhalation induces severe oxidative lung injury and airway
hyperresponsiveness (AHR) that lead to asthmalike symptoms. When inhaled, Cl2 reacts …

Low mw hyaluronan (LMW HA) has been shown to elicit the expression of proinflammatory
cytokines and chemokines in various cells in vitro. However, the effects of this molecule in …