Recent update and drug target in molecular and pharmacological insights into autophagy modulation in cancer treatment and future progress
Recent evidence suggests that autophagy is a governed catabolic framework enabling the
recycling of nutrients from injured organelles and other cellular constituents via a lysosomal …
recycling of nutrients from injured organelles and other cellular constituents via a lysosomal …
Autophagy paradox of cancer: Role, regulation, and duality
AK Verma, PS Bharti, S Rafat, D Bhatt… - Oxidative Medicine …, 2021 - Wiley Online Library
Autophagy, a catabolic process, degrades damaged and defective cellular materials through
lysosomes, thus working as a recycling mechanism of the cell. It is an evolutionarily …
lysosomes, thus working as a recycling mechanism of the cell. It is an evolutionarily …
Autophagy and cancer
KS Choi - Experimental & molecular medicine, 2012 - nature.com
Basal autophagy plays a critical role in maintaining cellular homeostasis and genomic
integrity by degrading aged or malfunctioning organelles and damaged or misfolded …
integrity by degrading aged or malfunctioning organelles and damaged or misfolded …
The evolving, multifaceted roles of autophagy in cancer
J Liu, J Debnath - Advances in cancer research, 2016 - Elsevier
Autophagy is a lysosomal degradation process crucial for adaptation to stress and cellular
homeostasis. In cancer, autophagy has been demonstrated to serve multifaceted roles in …
homeostasis. In cancer, autophagy has been demonstrated to serve multifaceted roles in …
Selective autophagy in cancer: mechanisms, therapeutic implications, and future perspectives
J Liu, Y Wu, S Meng, P Xu, S Li, Y Li, X Hu, L Ouyang… - Molecular cancer, 2024 - Springer
Eukaryotic cells engage in autophagy, an internal process of self-degradation through
lysosomes. Autophagy can be classified as selective or non-selective depending on the way …
lysosomes. Autophagy can be classified as selective or non-selective depending on the way …
Autophagy and cancer: dynamism of the metabolism of tumor cells and tissues
K Tsuchihara, S Fujii, H Esumi - Cancer letters, 2009 - Elsevier
Autophagy is a dynamic process involving the bulk degradation of cytoplasmic organelles
and proteins. Based on the function of “cellular recycling”, autophagy plays key roles in the …
and proteins. Based on the function of “cellular recycling”, autophagy plays key roles in the …
Tumor suppression and promotion by autophagy
Y Ávalos, J Canales, R Bravo-Sagua… - BioMed research …, 2014 - Wiley Online Library
Autophagy is a highly regulated catabolic process that involves lysosomal degradation of
proteins and organelles, mostly mitochondria, for the maintenance of cellular homeostasis …
proteins and organelles, mostly mitochondria, for the maintenance of cellular homeostasis …
Pro-survival autophagy: An emerging candidate of tumor progression through maintaining hallmarks of cancer
Autophagy is an evolutionary conserved catabolic process that regulates the cellular
homeostasis by targeting damaged cellular contents and organelles for lysosomal …
homeostasis by targeting damaged cellular contents and organelles for lysosomal …
Paradoxical roles of autophagy in different stages of tumorigenesis: protector for normal or cancer cells
Autophagy serves as a dynamic degradation and recycling system that provides biological
materials and energy in response to stress. The role of autophagy in tumor development is …
materials and energy in response to stress. The role of autophagy in tumor development is …
Autophagy: detection, regulation and its role in cancer and therapy response
P Hönscheid, K Datta, MH Muders - International journal of …, 2014 - Taylor & Francis
Purpose: Macroautophagy is a catabolic pathway that degrades cellular components
through the lysosomal machinery. Cytoplasmic components are sequestered in double …
through the lysosomal machinery. Cytoplasmic components are sequestered in double …