Recent update and drug target in molecular and pharmacological insights into autophagy modulation in cancer treatment and future progress

MA Rahman, ASM Saikat, MS Rahman, M Islam… - Cells, 2023 - mdpi.com
Recent evidence suggests that autophagy is a governed catabolic framework enabling the
recycling of nutrients from injured organelles and other cellular constituents via a lysosomal …

Autophagy paradox of cancer: Role, regulation, and duality

AK Verma, PS Bharti, S Rafat, D Bhatt… - Oxidative Medicine …, 2021 - Wiley Online Library
Autophagy, a catabolic process, degrades damaged and defective cellular materials through
lysosomes, thus working as a recycling mechanism of the cell. It is an evolutionarily …

Autophagy and cancer

KS Choi - Experimental & molecular medicine, 2012 - nature.com
Basal autophagy plays a critical role in maintaining cellular homeostasis and genomic
integrity by degrading aged or malfunctioning organelles and damaged or misfolded …

The evolving, multifaceted roles of autophagy in cancer

J Liu, J Debnath - Advances in cancer research, 2016 - Elsevier
Autophagy is a lysosomal degradation process crucial for adaptation to stress and cellular
homeostasis. In cancer, autophagy has been demonstrated to serve multifaceted roles in …

Selective autophagy in cancer: mechanisms, therapeutic implications, and future perspectives

J Liu, Y Wu, S Meng, P Xu, S Li, Y Li, X Hu, L Ouyang… - Molecular cancer, 2024 - Springer
Eukaryotic cells engage in autophagy, an internal process of self-degradation through
lysosomes. Autophagy can be classified as selective or non-selective depending on the way …

Autophagy and cancer: dynamism of the metabolism of tumor cells and tissues

K Tsuchihara, S Fujii, H Esumi - Cancer letters, 2009 - Elsevier
Autophagy is a dynamic process involving the bulk degradation of cytoplasmic organelles
and proteins. Based on the function of “cellular recycling”, autophagy plays key roles in the …

Tumor suppression and promotion by autophagy

Y Ávalos, J Canales, R Bravo-Sagua… - BioMed research …, 2014 - Wiley Online Library
Autophagy is a highly regulated catabolic process that involves lysosomal degradation of
proteins and organelles, mostly mitochondria, for the maintenance of cellular homeostasis …

Pro-survival autophagy: An emerging candidate of tumor progression through maintaining hallmarks of cancer

CK Das, I Banerjee, M Mandal - Seminars in Cancer Biology, 2020 - Elsevier
Autophagy is an evolutionary conserved catabolic process that regulates the cellular
homeostasis by targeting damaged cellular contents and organelles for lysosomal …

Paradoxical roles of autophagy in different stages of tumorigenesis: protector for normal or cancer cells

K Sun, W Deng, S Zhang, N Cai, S Jiao, J Song, L Wei - Cell & bioscience, 2013 - Springer
Autophagy serves as a dynamic degradation and recycling system that provides biological
materials and energy in response to stress. The role of autophagy in tumor development is …

Autophagy: detection, regulation and its role in cancer and therapy response

P Hönscheid, K Datta, MH Muders - International journal of …, 2014 - Taylor & Francis
Purpose: Macroautophagy is a catabolic pathway that degrades cellular components
through the lysosomal machinery. Cytoplasmic components are sequestered in double …