Autophagy: cancer's friend or foe?

SK Bhutia, S Mukhopadhyay, N Sinha, DN Das… - Advances in cancer …, 2013 - Elsevier
The functional relevance of autophagy in tumor formation and progression remains
controversial. Autophagy can promote tumor suppression during cancer initiation and …

[HTML][HTML] Molecular modulation of autophagy: New venture to target resistant cancer stem cells

HK Mandhair, M Arambasic, U Novak… - World journal of stem …, 2020 - ncbi.nlm.nih.gov
Autophagy is a highly regulated catabolic process in which superfluous, damaged
organelles and other cytoplasmic constituents are delivered to the lysosome for clearance …

Targeting cancer cells through autophagy for anticancer therapy

S Turcotte, AJ Giaccia - Current opinion in cell biology, 2010 - Elsevier
Autophagy is a cellular degradation process in which portions of the cell's cytoplasm and
organelles are sequestered in a double-membrane bound vesicle called an …

Autophagy modulation as a target for anticancer drug discovery

X Li, H Xu, Y Liu, N An, S Zhao, J Bao - Acta Pharmacologica Sinica, 2013 - nature.com
Autophagy, an evolutionarily conserved catabolic process involving the engulfment and
degradation of non-essential or abnormal cellular organelles and proteins, is crucial for …

Autophagy and autophagy-related pathways in cancer

J Debnath, N Gammoh, KM Ryan - Nature reviews Molecular cell …, 2023 - nature.com
Maintenance of protein homeostasis and organelle integrity and function is critical for
cellular homeostasis and cell viability. Autophagy is the principal mechanism that mediates …

Molecular pathways: autophagy in cancer—a matter of timing and context

M Cicchini, V Karantza, B Xia - Clinical cancer research, 2015 - AACR
Autophagy is an intracellular self-digestion mechanism, by which cellular components are
sorted into double-membrane autophagosomes and delivered to lysosomes for degradation …

[HTML][HTML] Unfolding the role of autophagy in the cancer metabolism

A Pandey, P Yadav, S Shukla - Biochemistry and Biophysics Reports, 2021 - Elsevier
Autophagy is considered an indispensable process that scavenges toxins, recycles complex
macromolecules, and sustains the essential cellular functions. In addition to its …

Autophagy and cancer: Basic mechanisms and inhibitor development

Y Hama, Y Ogasawara, NN Noda - Cancer Science, 2023 - Wiley Online Library
Autophagy is a lysosomal degradation system of cytoplasmic components that contributes to
cellular homeostasis through the turnover of various biomolecules and organelles, often in a …

Autophagy: an emerging target for cancer therapy

M Høyer-Hansen, M Jäättelä - Autophagy, 2008 - Taylor & Francis
Macroautophagy (hereafter referred to as autophagy) is a lysosomal catabolic pathway
whereby cells recycle macromolecules and organelles. The capacity of autophagy to …

Autophagy and tumorigenesis

M Rangel, J Kong, V Bhatt, K Khayati… - The FEBS …, 2022 - Wiley Online Library
Autophagy is a catabolic process that captures cellular waste and degrades them in the
lysosome. The main functions of autophagy are quality control of cytosolic proteins and …