Trichomonas vaginalis, a flagellated protozoan parasite, is the causative organism of
trichomoniasis. We have recently demonstrated that T. vaginalis induces apoptotic cell death …

Chlamydia is an obligate intracellular pathogen that develops in the host cell in a vacuole
termed the chlamydial inclusion. The prevailing concept of the chlamydial inclusion is of a …

Control of host cell death is of paramount importance for the survival and replication of
obligate intracellular bacteria. Among these, human pathogenic Chlamydia induces the …

Syphilis is a persistent sexually transmitted disease caused by infiltration of the elusive
pathogen Treponema pallidum. Despite the prevalence of human polymorphonuclear …

Dendritic cells (DCs) and natural killer (NK) cells are critically involved in the early response
against various bacterial microbes. Functional activation of infected DCs and NK cell …

Chlamydia pneumoniae is a ubiquitous intracellular bacterium which infects humans via the
respiratory route. The tendency of C. pneumoniae to persist in monocytes and macrophages …

Abstract Type I IFNs (IFNIs) have pleiotropic functions in regulating host innate and adaptive
immune responses to pathogens. To elucidate the role of IFNIs in host resistance to …

The obligate intracellular bacterium Chlamydia trachomatis inserts a family of inclusion
membrane (Inc) proteins into the membrane of its vacuole (the inclusion). The Inc CpoS is a …

Autophagy can either antagonize or promote intracellular bacterial growth, depending on
the pathogen. Here, we investigated the role of autophagy during a pulmonary infection with …

Chlamydiae are obligate intracellular pathogens replicating only inside the eukaryotic host.
Here, we studied the effect of human flotillin-1 protein on Chlamydia pneumoniae growth in …