In cystic fibrosis (CF), a lack of functional CF transmembrane conductance regulator (CFTR)
chloride channels causes defective secretion by submucosal glands (SMGs), leading to …

Submucosal glands (SMGs) are the major site of expression of the cystic fibrosis (CF)
transmembrane conductance regulator gene (CFTR) in the human lung. As such, SMGs may …

Rationale: Identification of the specific cell types expressing CFTR (cystic fibrosis [CF]
transmembrane conductance regulator) is required for precision medicine therapies for CF …

Loss of cystic fibrosis transmembrane conductance regulator (CFTR) function reduces
chloride secretion and increases sodium uptake, but it is not clear why CFTR mutation also …

Submucosal glands line the cartilaginous airways and produce most of the antimicrobial
mucus that keeps the airways sterile. The glands are defective in cystic fibrosis (CF), but how …

Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene cause
the life-limiting hereditary disease, cystic fibrosis (CF). Decreased or absent functional CFTR …

Airway submucosal glands are important sites of cystic fibrosis transmembrane conductance
regulator (CFTR) chloride (Cl−) channel expression and fluid secretion in the airway …

Lack of CFTR (cystic fibrosis transmembrane conductance regulator) affects the
transcriptome, composition, and function of large and small airway epithelia in people with …

Cystic Fibrosis (CF) is a recessive genetic disease due to mutations of the Cystic Fibrosis
Transmembrane Conductance Regulator (CFTR) gene encoding the CFTR chloride …

Cultured airway epithelial cells are widely used in cystic fibrosis (CF) research as in vitro
models that mimic the in vivo manifestations of the disease and help to define a specific …