Synthesis and antiviral activities of phenanthroindolizidine alkaloids and their derivatives

K Wang, BO Su, Z Wang, M Wu, Z Li, Y Hu… - Journal of agricultural …, 2010 - ACS Publications
Racemic phenanthroindolizidine alkaloids tylophorine, antofine, and deoxytylophorinine,
and optically pure alkaloids S-(+)-tylophorine and R-(−)-tylophorine were synthesized and …

Design, synthesis, and anti-tobacco mosaic virus (TMV) activity of phenanthroindolizidines and their analogues

Z Wang, P Wei, L Wang, Q Wang - Journal of agricultural and food …, 2012 - ACS Publications
On the basis of our previous structure–activity relationship (SAR) and antiviral mechanism
studies, a series of phenanthroindolizidines and their analogues 3–20 were designed …

Design, synthesis, and antitobacco mosaic virus activity of water-soluble chiral quaternary ammonium salts of phenanthroindolizidines alkaloids

G Han, L Chen, Q Wang, M Wu, Y Liu… - Journal of agricultural …, 2018 - ACS Publications
To study the influence of the substituent at the N-10 position on antiviral activity, the chiral
quaternary ammonium salt derivatives of R-and S-tylophorine were designed, synthesized …

Design, synthesis, and antiviral evaluation of phenanthrene-based tylophorine derivatives as potential antiviral agents

K Wang, Y Hu, Y Liu, N Mi, Z Fan, Y Liu… - Journal of agricultural …, 2010 - ACS Publications
A series of C9-substituted phenanthrene-based tylophorine derivatives (PBTs) were
designed, synthesized, and first evaluated for their antiviral activities against tobacco mosaic …

Target-directed design, synthesis, antiviral activity, and SARs of 9-substituted phenanthroindolizidine alkaloid derivatives

C Yan, J Dong, Y Liu, Y Li, Q Wang - Journal of Agricultural and …, 2021 - ACS Publications
On the basis of our previous studies on the antiviral mechanism against tobacco mosaic
virus (TMV) and structure–activity relationship of phenanthroindolizidine alkaloids, a series …

Design, synthesis, antiviral activity, and SARs of 14-aminophenanthroindolizidines

Z Wang, L Wang, S Ma, Y Liu, L Wang… - Journal of agricultural …, 2012 - ACS Publications
Based on our previous structure–activity relationship and antiviral mechanism studies, a
series of 14-aminophenanthroindolizidines (1a–i, 2, and 3) were designed, targeting …

Design, synthesis, antiviral activity, and SARs of 13a-substituted phenanthroindolizidine alkaloid derivatives

B Su, C Cai, M Deng, D Liang, L Wang… - Bioorganic & Medicinal …, 2014 - Elsevier
On the basis of our previous structure–activity relationship (SAR) and antiviral mechanism
studies, a series of 13a-substituted phenanthroindolizidine alkaloid analogues (3a–16a, 3b …

[HTML][HTML] First Discovery and Stucture-Activity Relationship Study of Phenanthroquinolizidines as Novel Antiviral Agents against Tobacco Mosaic Virus (TMV)

Z Wang, A Feng, M Cui, Y Liu, L Wang, Q Wang - PLoS One, 2012 - journals.plos.org
A series of phenanthroquinolizidine alkaloids 1–24 were prepared and first evaluated for
their antiviral activity against tobacco mosaic virus (TMV). The bioassay results showed that …

Spatial configuration and three-dimensional conformation directed design, synthesis, antiviral activity, and structure–activity relationships of phenanthroindolizidine …

B Su, C Cai, M Deng, Q Wang - Journal of agricultural and food …, 2016 - ACS Publications
Our recent investigation on the antiviral activities against tobacco mosaic virus (TMV) of
phenanthroindolizidine alkaloid analogues preliminarily revealed that the basic skeleton …

Design, synthesis, and antiviral activity evaluation of phenanthrene-based antofine derivatives

Z Wang, P Wei, X Xizhi, Y Liu, L Wang… - Journal of agricultural …, 2012 - ACS Publications
On the basis of our previous structure–activity relationship (SAR) and antiviral mechanism
studies, a series of phenanthrene-based antofine derivatives (1–12 and 18–50) were …