Immunotoxins are chimeric proteins composed of an antibody domain that specifically
directs the action of the toxic domain, resulting in the death of the targeted cells. Over recent …

Targeted cancer therapy includes, amongst others, antibody-based delivery of toxic
payloads to selectively eliminate tumor cells. This payload can be either a synthetic small …

Immunotoxins are chimeric molecules that specifically target tumor cells, as they are made
up of toxins linked to an antibody directed to a specific, cell-surface tumor-associated …

Immunotoxins are chimeric molecules that combine the specificity of an antibody to
recognize and bind tumor antigens with the potency of the enzymatic activity of a toxin, thus …

Bovine seminal ribonuclease (BSRNase) is an unusual member of the ribonuclease
superfamily, because of its remarkable anti-tumour and immunosuppressive properties. We …

Plant Ribosome-inactivating proteins (RIPs) including the type I RIP Saporin have been
used for the construction of Immunotoxins (ITxs) obtained via chemical conjugation of the …

Immunotoxins are a novel class of cancer therapeutics that contains a cytotoxic agent fused
to a targeting moiety. Various toxic agents from different sources are used in immunotoxin …

The aim of this study was to determine the suitability of a ribosome-inactivating protein (RIP)
from barley endosperm for use as an immunotoxin. This barley RIP is identical with the 30 …

Publisher Summary This chapter reviews preclinical findings that predict that there is a role
for monoclonal antibody (MAb)-based drug conjugates and immunotoxins for the targeted …

Ribotoxins constitute a family of toxic extracellular fungal RNases that exert a highly specific
activity on a conserved region of the larger molecule of rRNA, known as the sarcin-ricin loop …